My project focuses on addressing genetic diseases caused by premature termination codons (PTCs), which lead to truncated, non-functional proteins by prematurely terminating mRNA translation. The main goal is to develop strategies to promote the readthrough of PTCs using specially designed suppressor tRNAs, aiming to restore full-length protein expression and alleviate disease phenotypes. Additionally I am interested in the fundamental mechanisms of translation termination to deepen our understanding of translational readthrough processes. Utilizing a combination of computational modeling and various laboratory techniques, this research seeks to improve therapeutic outcomes for PTC-associated genetic disorders.
