New Publications

22. April 2026, von Leonhardt

Foto: RG Wicha

We are excited to share that in the past weeks, two papers were published in our group.

Aneeq Farooq et al. present an evidence-based, pharmacometrics-driven rationale for combined breakpoints for meropenem and fosfomycin in his article "Meropenem and fosfomycin against Klebsiella pneumoniae: Towards a combination breakpoint using a pharmacometric approach". Given the rising prevalence of ESBL- and carbapenemase-producing K. pneumoniae and the limited treatment options for multidrug-resistant infections, the potential of this combination therapy is particularly important. Our simulations revealed support for evaluating expanded combination breakpoints beyond those currently applied in monotherapy.

Christoph Pfaffendorff et al. describe pharmacokinetics of anti-malarian drugs in the publication "Population pharmacokinetics of fosmidomycin and clindamycin in combination with artesunate for uncomplicated Plasmodium falciparum malaria in Gabonese children and adults".  Body weight significantly influenced clearance and volume of distribution for both drugs. Additionally, body temperature impacted fosmidomycin clearance, with increased clearance during febrile episodes. Weight-based dosing achieved consistent fosmidomycin exposure across age groups, but clindamycin exposure was lower in young children compared to adolescents and adults. Simulations indicate that increasing the clindamycin dose from 10 mg/kg to 12 mg/kg in children under 35 kg could achieve drug exposure levels comparable to older patients.