Research

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

 

KEY PUBLICATIONS

Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine
Wang C, Kassem S, Rocha REO, Sun P, Nguyen TT, Kloehn J, Liu X, Brusini L, Bonavoglia A, Barua S, Boissier F, Lucia Del Cistia M, Peng H, Tang X, Xie F, Wang Z, Vadas O, Suo X, Hashem Y, Soldati-Favre D, Jia Y (2024). Nature Commun. 15:10689.
https://www.nature.com/articles/s41467-024-55033-z

A rapid, facile, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
Erath J, Kemper D, Mugo E, Jacoby A, Valenzuela E, Jungers CF, Beatty WL, Hashem Y, Jovanovic M, Djuranovic S, Djuranovic SP (2025). Nature Commun. 16:7185.
https://www.nature.com/articles/s41467-025-62314-8

N6-methyladenosine in 5′ UTR does not promote translation initiation
Guca E, Alarcon R, Palo MZ, Santos L, Alonso-Gil S, Davyt M, de Lima LHF, Boissier F, Das S, Zagrovic B, Puglisi JD, Hashem Y, Ignatova Z (2024). Mol Cell. 15:S1097-2765(23)01074-2.
https://www.sciencedirect.com/science/article/pii/S1097276523010742