Research

The group of Dr. Suki Albers-Fomenko is investigating

tRNA biogenesis
tRNA function in health & disease
tRNA therapeutics

KEY PUBLICATIONS

Suppressor tRNAs as personalized therapy for nonsense mutation-associated pathologies.
Ignatova Z, Albers S. Pharmacol Ther. 2025 Oct;274:108919. doi: 10.1016/j.pharmthera.2025.108919. Epub 2025 Aug 22. PMID: 40850535
https://pubmed.ncbi.nlm.nih.gov/40850535/

Engineered tRNAs suppress nonsense mutations in cells and in vivo.
Albers S, Allen EC, Bharti N, Davyt M, Joshi D, Perez-Garcia CG, Santos L, Mukthavaram R, Delgado-Toscano MA, Molina B, Kuakini K, Alayyoubi M, Park KJ, Acharya G, Gonzalez JA, Sagi A, Birket SE, Tearney GJ, Rowe SM, Manfredi C, Hong JS, Tachikawa K, Karmali P, Matsuda D, Sorscher EJ, Chivukula P, Ignatova Z. Nature. 2023 Jun;618(7966):842-848. doi: 10.1038/s41586-023-06133-1. Epub 2023 May 31. PMID: 37258671
https://pubmed.ncbi.nlm.nih.gov/37258671/

Repurposing tRNAs for nonsense suppression.
Albers S, Beckert B, Matthies MC, Mandava CS, Schuster R, Seuring C, Riedner M, Sanyal S, Torda AE, Wilson DN, Ignatova Z. Nat Commun. 2021 Jun 22;12(1):3850. doi: 10.1038/s41467-021-24076-x. PMID: 34158503
https://pubmed.ncbi.nlm.nih.gov/34158503/