Several genetic disorders alter translational households in cells. In my project I integrate various in silico approaches, e.g. molecular dynamics simulations, AI-assisted optimization, and multi-scale modeling, to develop tRNAs for various therapeutic modalities. This includes suppressor tRNAs for targeting nonsense-associated pathologies, or tRNA supplementation strategies for Charcot-Marie-Tooth disease. I work closely with experimentalists in the group: promising candidates in my analysis are validated experimentally.
