Ribosomal composition across age and tissues
Protein homeostasis is believed to decline with age and many age-related diseases are caused by translational dysregulation and primarily affect brain tissues. Ribosomes are central to proteostasis. Ribosomes are not rigid bodies and are likely to have highly variable structures. The ribosomal composition is crucial for translation fidelity. Several reports have suggested variations in ribosome composition with likely consequences for gene expression of a sizeable subset of mRNAs. In my research project I study possible changes in the ribosomal composition upon aging in both brain and liver tissues of mice.