Research

Membrane proteins are essential for signal transduction and the transfer of proteins and small molecules across the biological membrane. Our research is focused on structural biology of integral membrane proteins. We are particularly interested in Ca2+ transport and signaling, vitamin transport, and intramembrane proteases. In addition, we develop methods for time-resolved structural studies and apply novel membrane mimics to biologically interesting systems.

KEY PUBLICATIONS

Structural insights into a novel family of integral membrane siderophore reductases
Josts, I., Veith, K., Normant, V., Schalk, I.J., and Tidow, H.
Proc Natl Acad Sci U S A, 118(34) :e2101952118 (2021) 
https://pubmed.ncbi.nlm.nih.gov/34417315/

Structural Kinetics of MsbA Investigated by Stopped-Flow Time-Resolved Small-Angle X-Ray Scattering
Josts, I., Gao, Y., Monteiro, D.C.F., Niebling, S., Nitsche, J., Veith, K., Gräwert, T.W., Blanchet, C.E., Schroer, M.A., Huse, N., Pearson, A.R., Svergun, D.I., and Tidow, H.
Structure, 28(3): 348-354 (2020)
https://pubmed.ncbi.nlm.nih.gov/31899087/

Ternary structure of the outer membrane transporter FoxA provides insights into TonB-mediated siderophore uptake
Josts, I., Veith, K., and Tidow, H.
Elife 8, doi: 10.7554/eLife.48528 (2019)
https://pubmed.ncbi.nlm.nih.gov/31385808/