New publication “Assessing parameter uncertainty in small-n pharmacometric analyses: value of the log-likelihood profiling-based sampling importance resampling (LLP-SIR) technique.”
8. April 2020, von Kroemer
Small datasets appear regularly in pharmacometric analyses, especially when dealing with special patient populations. In this paper, Astrid Broeker from our team investigated which method is most suited to determine the uncertainty of the estimated pharmacometric model parameters in small-n pharmacometric studies. The paper was published in the Journal of Pharmacokinetics and Pharmacodynamics. Congratulations!