Intramembrane-cleaving metalloprotease, site-2-protease (S2P), activates membrane-bound transcription factors together with site-1-protease. Missense mutations in S2P result in disorders that primarily affect skin and bone tissue at different degrees. My project aims to dissect the molecular pathways and factors affected by S2P in osteoblasts, in the context of stress and differentiation. I am also analyzing the activity of individual mutants in an S2P-knockout background using a combined approach of -omics, fluorescence microscopy, structural bioinformatics and molecular biology techniques.
