Premature Termination Codons (PTC) are simply stop codons that occur erroneously in open reading frames of functional mRNAs. The PTCs lead to premature termination of protein synthesis and functional loss. These can be corrected in multiple ways such as repurposing tRNAs to correct these PTCs and allow normal translation to resume. These targeted corrections are influenced by the information surrounding PTCs, including nucleotide identities, modifications, position of PTCs in the mRNA etc. Our goal is to understand which factors influence the correctivity at each PTCs, in a way that we can predict the degree by which a PTC can be corrected.
