Time-resolved experiments to study conformational changes of homo- and heterodimeric ABC transporters in solution

14 August 2024, by Dr. Henning Tidow

Schematische Darstellung der Untersuchungen zu ABC-Transportern

Photo: Dr. Henning Tidow

ATP-binding cassette (ABC) transporters catalyze substrate translocation across cellular membranes and are ubiquitously expressed in all domains of life. The reaction cycle of ABC transporters is still not completely understood. In the context of his Heisenberg group Henning Tidow seeks to understand the complete reaction cycle of homo- and heterodimeric ABC transporters using a combination of small-angle neutron scattering (SANS) in lipidic carrier systems, time-resolved small-angle X-ray scattering (TR-SAXS) guided by specific nanobodies trapping the transporters in defined states and time-resolved cryo-electron microscopy (TR-EM). Our ultimate goal is to identify the accompanying structural transitions with high temporal resolution. This project is funded by the DFG with up to 270.000 Euro.

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