Associated Member: Roland Schauer
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Investigation of Sialic Acid O-Acetyltransferases
Sialic acids occur in a great variety of chemical modifications. Among these O-acetylated forms are wide-spread in man, animals and some microorganisms. Two enzyme systems are known to O-acetylate sialic acids: A sialate 4-O-acetyltransferase and a corresponding enzyme incorporating acetyl groups into the sialic acid side chain, probably first at O-7. Both enzymes have been solubilized from Golgi membranes of guinea pig liver and bovine submandibular gland, respectively. These enzymes will be purified and characterized, followed by molecular cloning based on enzyme peptide sequences. O-Acetylated sialic acids are gaining increasing attention, since they are involved in many biological processes such as development, immunology and cell recognition. They also play a role in pathological processes such as viral infections and represent tumour markers. The projects is supported by a grant from the Deutsche Forschungsgemeinschaft (DFG SCHA 202/33-1).Contact:
Prof. (em.) Dr. med. Dipl.-Biochem. Roland SchauerAddress:
Biochemisches Institut
Christian-Albrechts-Universität
Olshausenstr. 40
D-24098 Kiel, Germany
Telefon: +49-431-8802210
Telefax: +49-431-8802238
E-Mail: schauer@biochem.uni-kiel.de
www.uni-kiel.de/Biochemie/AGSch/index.htm