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Associated Member: Roland Schauer

Keywords: Sialic acid; O-acetylation; enzyme purification and cloning; biological functions; tumour markers

Investigation of Sialic Acid O-Acetyltransferases

Sialic acids occur in a great variety of chemical modifications. Among these O-acetylated forms are wide-spread in man, animals and some microorganisms. Two enzyme systems are known to O-acetylate sialic acids: A sialate 4-O-acetyltransferase and a corresponding enzyme incorporating acetyl groups into the sialic acid side chain, probably first at O-7. Both enzymes have been solubilized from Golgi membranes of guinea pig liver and bovine submandibular gland, respectively. These enzymes will be purified and characterized, followed by molecular cloning based on enzyme peptide sequences. O-Acetylated sialic acids are gaining increasing attention, since they are involved in many biological processes such as development, immunology and cell recognition. They also play a role in pathological processes such as viral infections and represent tumour markers. The projects is supported by a grant from the Deutsche Forschungsgemeinschaft (DFG SCHA 202/33-1).


Prof. (em.) Dr. med. Dipl.-Biochem. Roland Schauer

Biochemisches Institut
Olshausenstr. 40
D-24098 Kiel, Germany

Telefon: +49-431-8802210
Telefax: +49-431-8802238

Last Change: 15.02.2004 by Matthias Vill
Contact: Martina Krasa