B3: Aufklärung molekularer Erkennungsmotive in Glycosyltransferase/Ligand-Komplexen
The mechanism of glycosyltransferases is investigated utilizing different biophysical techniques. The most important tool is high-field NMR spectroscopy that is employed to define the bioactive conformations of donor- and acceptor-ligands as well as their binding epitopes.
Using uniform and amino acid selective isotope labeling with 15N, 13C, and 2H we also investigate the protein conformation and the topology of the binding site.
Our current interest is focussed on galactosyl- and sialyltransferases.
Contact:
|
Prof. Dr. Thomas Peters Address: Universität Lübeck Institut für Chemie Ratzeburger Allee 160 23538 Lübeck Telefon: 0451-500-4230 Telefax: 0451-500-4241 E-Mail: thomas.peters@chemie.mu-luebeck.de http://www.chemie.mu-luebeck.de/ |
|