University of Hamburg
Department of Chemistry
Faculty of Sciences
phone: +49 40 42838 -2810
fax: +49 40 42838 -4325
ROOM - OC 322
Successfully completed his master degree in 2011 entitled "New studies of Glycosylations with Complex Oxianion Saccharide-Derivatives".
A mechanistic illustration is shown in Scheme 1, illustrating the differences between conventional glycosylations using protecting group chemistry and by using a base promoted approach, which potentially allows for a reactivity based regioselective glycosylation. [1-2]
Scheme 1. Conventional glycosylation methodology and base promoted glycosylation via generating "oxyanion(s)"
In my doctoral thesis one focus is on the synthesis of new indoxyl glycosides.
Enzymatic hydrolysis of indoxyl glycosides yields the free indoxyl derivative which is oxidized by oxygen to indigo
type dye. This represents a straight forward approach for the detection of enzyme activities. 
Scheme 2. Enzyme activity monitoring via indoxyl glycosides
 Matwiejuk M., Thiem J. Chem Commun 2011, 47, 8379-8381
 Matwiejuk M., Thiem J. Eur. J. Org. Chem. 2011, 5860-5878.
 S. Boettcher, M. Matwiejuk, J. Thiem, Beilstein J. Org. Chem. 2012, 8, 413-420.
 S. Boettcher, J. Thiem, unpublished results (master thesis University of Hamburg 2011)
 J. A. Kiernan, Biotechnic & Histochemistry 2007