Publications

• (6) University of Oxford - Department of Chemistry
  Dr. Stuart Conway
  Mansfield Road - Oxford OX1 3TA - United Kingdom
  Website - e-mail: stuart.conway[at]chem.ox.ac.uk
  Tel: +44 (0)1865 285 109
  

1. Brand M, Measures AM, Wilson BG, Cortopassi WA, Alexander R, Höss M, Hewings DS, Rooney TP, Paton RS, Conway SJ (2015) Small molecule inhibitors of bromodomain-acetyl-lysine interactions. ACS Chem Biol. 10, 22-39.
2. Healy J, Ekkerman S, Pliotas C, Richard M, Bartlett W, Grayer SC, Morris GM, Miller S, Booth IR, Conway SJ, Rasmussen T. (2014) Understanding the structural requirements for activators of the Kef bacterial potassium efflux system. Biochem. 53, 1982-92
   .:Collaborative Publication:.
   
3. Cazares-Koerner, C., Pires, I. M., Swallow, I.D, Grayer, S.C., O’Connor, L. Olcina, M. M. Christlieb, M., Conway, S. J., Hammond, E.M. (2013) CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A. ACS Chem. Biol. 8, 1451-1459.
4. Hewings, D.S., Fedorov, O., Filippakopoulos, P., Martin, S., Picaud, S., Tumber, A., Wells, C., Olcina, M.M., Freeman, K., Gill, A., Ritchie, A.J., Sheppard, D.W. Russell, A.J. Hammond, E. M., Knapp, S., Brennan, P.E., and Conway, S.J. (2013) Optimization of 3,5-dimethylisoxazole derivatives as potent BET bromodomain ligands. J. Med. Chem.56, 3217-3227.
5. Hay, D., Fedorov, O., Filippakopoulos, P., Martin, S., Philpott, M., Hewings, D., Uttakar, S.S,  Heightman, T.D, Conway, S. J., Knapp, S., and Brennan, P. E. (2013) The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of BET bromodomains. Med. Chem. Commun. 4, 140-144.
6. Davis, L.C., Morgan, A.J., Chen, J-.L., Snead, C., Bloor-Young, D., Stanton-Humphreys, M.N.,Conway, S.J., Shenderov, E., Churchill, G.C., Parrington, J., Cerundolo, V., and Galione, A. (2012) NAADP activates two-pore channels on T-cell cytolytic granules to stimulate exocytosis and killing. Curr. Biol. 22, 2331-2337.
7. Stanton-Humphreys, M.N., Taylor, R.D.T., McDougall, C., Hart, M.L., Brown, C.T.A., Emptage, N.J. and Conway, S.J. (2012) Wavelength-orthogonal photolysis of neurotransmitters in vitro. Chem. Commun. 48, 657-59.