Signal-enhanced magnetic resonance – A tool for chemistry and biology
Wann: Do, 13.01.2022, 16:15 Uhr bis 17:45 Uhr
Wo: Fachbereich Chemie, Martin-Luther-King-Platz 6, 20146 Hamburg, Hörsaal B
Dr. Stefan Glöggler, Max-Planck-Institut für Biophysikalische Chemie
Magnetic resonance is a phenomenon that has massively impacted our world with applications in e.g. analytical chemistry and medical imaging. Despite its importance, magnetic resonance is an inherently insensitive phenomenon. Signal enhancement or hyperpolarization strategies aim at amplifying normal magnetic resonance signals by multiple orders of magnitude. Signals that are larger than 10 000-fold allow for new approaches to perform chemical analysis, study biochemical reactions in real-time and for clinical diagnostics. The use of para-hydrogen, a spin isomer of normal hydrogen gas, has paved pathways for a simple approach to obtain enhanced magnetic resonance signals within seconds and make use of it to study metabolic events in cells and even in complex organisms. These recent developments do not only offer perspectives to investigate biochemical processes from another angle but also open up a field for synthesizing new molecular probes. Such probes will enable us in the future to detect diseases much more efficiently than with state-of-the-art approaches.