Inhalt:
Kurzbiographie
| 1967 | geboren am 20. Januar 1967 in Flensburg |
| 1993 | Approbation als Apotheker |
| 1996 | Promotion bei Conrad Kunick in Hamburg |
| 1996-1997 | PostDoc bei Piet Herdewijn am Rega Institut für medizinische Forschung in Leuven, Belgien |
| 1997 | Glaxo Wellcome Innovations-Preis für die Hamburger Pharmazie 1995/1996 |
| 2001 | Innovationspreis der GDCh-Fachgruppe Medizinische Chemie und der Fachgruppe Pharmazeutische/Medizinische Chemie der DPhG |
| 2002 | Habilitation in Hamburg |
| 2002 | Vertretungsprofessur (C3) am Institut für Pharmazeutische Chemie, Fachbereich Pharmazie, der Philipps-Universität Marburg |
| 2002-2004 | Professur für Pharmazeutische Chemie (C3) Nachfolge Prof. Dr. Manfred Haake, am Fachbereich Pharmazie der Philipps-Universität Marburg |
| 2004- | Professur für Pharmazeutische/Medizinische Chemie (C4) Nachfolge Prof. Dr. Hans-Hartwig Otto am Institut für Pharmazie der Ernst-Moritz-Arndt-Universität Greifswald |
Weitere Informationen
Publikationen
(nur bis zum Ende Hamburger Zeit, bis 2002)2002 | |
| 1 |
Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker Abolfasl Golisade; Claudia Herforth; Ludo Quirijnen; Louis Maes; Andreas Link Bioorganic & Medicinal Chemistry 10, 159-165 (2002) |
| 2 |
Anti-Malarial activity of N6-Substituted adenosine derivatives. Part I Abolfasl Golisade; Jochen Wiesner; Claudia Herforth; Hassan Jomaa; Andreas Link Bioorganic & Medicinal Chemistry 10, 769-777 (2002) |
| 3 |
Dynamite approach to delicate complex scaffolds Andreas Link Drug Discovery Today 7, 548-549 (2002) |
| 4 |
Antimalarial Activity of N6-Substituted Adenosine Derivatives (Part 2) Claudia Herforth; Jochen Wiesner; Stephan Franke; Abolfasl Golisade; Hassan Jomaa; Andreas Link Journal of Combinatorial Chemistry 4, 302-314 (2002) |
| 5 |
5'-Deoxy Congeners of 9-(3-Amido-3-deoxy-β-D-xylofuranosyl)-N6-cyclopentyladenine: New Adenosine A1 Receptor Antagonists and Inverse Agonists Serge van Calenbergh; Andreas Link; Shelly Fujikawa; Rianne A. F. de Ligt; Veerle Vanheusden; Abolfasl Golisade; Norbert M. Blaton; Jef Rozenski; Adriaan P. IJzerman; Piet Herdewijn Journal of Medicinal Chemistry 45, 1845-1852 (2002) |
| 6 |
Paullone als selektive Kinase-Inhibitoren (Drug research: paullones as selective kinase inhibitors) Conrad Kunick; Thomas Lemcke Pharmazeutische Zeitung 147, 2428-2435 (2002) |
| 7 |
Triptane - neuere Entwicklungen: In der Pipeline (In the pipeline: triptans - newer developments) Andreas Link; Britta Link Pharmazie in Unserer Zeit 31, 486-493 (2002) |
| 8 |
Konvergente polymerunterstützte Parallelsynthese von Adenosinanaloga Andreas Link Habilitationsschrift, Hamburg (2002) |
| 9 |
Amine-modified nucleosides as adenosine A3 neoceptor ligands Philippe van Rompaey; Kenneth A. Jacobson; Zhan-Guo Gao; Aishe Chen; Dov Barak; Soon-Ai Kim; Kyeong Lee; Andreas Link; Bruce T. Liang; Piet Herdewijn; Serge van Calenbergh Collection Symposium Series 5 (Chemistry of Nucleic Acid Components) 267-271 (2002) |
| 10 |
Synthesis of chemoselective biotinylation agent and application Andreas Link Patent: DE 10101397 (A1) 2002-07-25 |
2001 | |
| 11 |
Aryl rings are part of the darpone pharmacophore Christiane Schultz; Andreas Link; Conrad Kunick Archiv der Pharmazie 334, 163-166 (2001) |
| 12 |
Biotin labelling of amines by polymer-assisted solution-phase synthesis Abolfasl Golisade; Claudia Herforth; Karen Wieking; Conrad Kunick; Andreas Link Bioorganic & Medicinal Chemistry Letters 11, 1783-1786 (2001) |
| 13 |
Neoceptor concept based on molecular complementarity in GPCRs: A mutant adenosine A3 receptor with selectively enhanced affinity for amine-modified nucleosides Kenneth A. Jacobson; Zhan-Guo Gao; Aishe Chen; Dov Barak; Soon-Ai Kim; Kyeong Lee; Andreas Link; Philippe van Rompaey; Serge van Calenbergh; Bruce T. Liang Journal of Medicinal Chemistry 44, 4125-4136 (2001) |
| 14 |
Wirkstoff-Entwicklung: Maßgeschneiderte Nadeln aus dem kombinatorischen Heuhaufen (Active substance development: custom-made needles from combinatoric haystacks) Andreas Link Pharmazeutische Zeitung 146, 3760-3766 (2001) |
| 15 |
Novel N6-substituted adenosines: Synthesis and biological evaluation as anti-malarial agents Abolfasl Golisade; Claudia Herforth; Jochen Wiesner; Andreas Link Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001 MEDI-M243 (2001) |
| 16 |
Biotin labeling of nucleoside derivatives via polymer assisted solution phase (PASP) synthesis Claudia Herforth; Abolfasl Golisade; Andreas Link Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001 MEDI-M311 (2001) |
2000 | |
| 17 |
Comments on the terminology for applications of temporarily attached solubility-modifying moieties in combinatorial chemistry Andreas Link Angewandte Chemie, International Edition 39, 4039-4040 (2000) |
| 18 |
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition Rick Gussio; Daniel W. Zaharevitz; Connor F. McGrath; Nagarajan Pattabiraman; Glen E. Kellogg; Christiane Schultz; Andreas Link; Conrad Kunick; Maryse Leost; Laurent Meijer; Edward A. Sausville Anti-Cancer Drug Design 15, 53-66 (2000) |
| 19 |
Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-dependent kinase 5/p25 Maryse Leost; Christiane Schultz; Andreas Link; Yong-Zhong Wu; Jacek Biernat; Eva-Maria Mandelkow; James A. Bibb; Gretchen L. Snyder; Paul Greengard; Daniel W. Zaharevitz; Rick Gussio; Adrian M. Senderowicz; Edward A. Sausville; Conrad Kunick; Laurent Meijer European Journal of Biochemistry 267, 5983-5994 (2000) |
| 20 |
Polymer-Assisted Solution-Phase Synthesis of 2'-Amido-2'-deoxyadenosine Derivatives Targeted at the NAD+/-Binding Sites of Parasite Enzymes Abolfasl Golisade; Jerome C. Bressi; Serge Calenbergh; Michael H. Gelb; Andreas Link Journal of Combinatorial Chemistry 2, 537-544 (2000) |
| 21 |
2'-Amino-2'-deoxy-N6-(1-naphthylmethyl)adenosine as a novel scaffold for polymer-assisted amidation protocol Abolfasl Golisade; Serge van Calenbergh; Andreas Link Tetrahedron 56, 3167-3172 (2000) |
1999 | |
| 22 |
Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity Christiane Schultz; Andreas Link; Maryse Leost; Daniel W. Zaharevitz; Rick Gussio; Edward A. Sausville; Laurent Meijer; Conrad Kunick Journal of Medicinal Chemistry 42, 2909-2919 (1999) |
| 23 |
Antitumor pyrido[3,2-d][1]benzazepines. Synthesis and in vitro activity of thiophene analogs Andreas Link; Daniel W. Zaharevitz; Conrad Kunick Pharmazie 54, 163-166 (1999) |
| 24 |
Exploration of the effect of sterically demanding 3'-amido substitution of 3'-deoxyadenosines towards inhibition of cyclin-dependent kinase 1 Serge van Calenbergh; Andreas Link; Conrad Kunick; Piet Herdewijn Pharmazie 54, 727-729 (1999) |
| 25 |
5'-Deoxy congeners of 9-(3-amido-3-deoxy-β-D-xylofuranosyl)-N6-cyclopentyladenine: New adenosine A1 receptor antagonists Serge van Calenbergh; Andreas Link; Shelly Fujikawa; Veerle Vanheusden; Denis De Keukeleire; Adriaan P. IJzerman; Piet Herdewijn Collection Symposium Series 2 (Chemistry of Nucleic Acid Components) 273-276 (1999) |
1998 | |
| 26 |
DNA-binding ligands from peptide libraries containing unnatural amino acids Theo Lescrinier; Chris Hendrix; Luc Kerremans; Jef Rozenski; Andreas Link; Bart Samyn; Arthur Van Aerschot; Eveline Lescrinier; Ramon Eritja; Jozef Van Beeumen; Piet Herdewijn Chemistry - A European Journal 4, 425-433 (1998) |
| 27 |
d-Fused [1]Benzazepines with Selective in Vitro Antitumor Activity: Synthesis and Structure-Activity Relationships Andreas Link; Conrad Kunick Journal of Medicinal Chemistry 41, 1299-1305 (1998) |
| 28 |
Side reactions in solid-phase peptide synthesis caused by sulfonyl-ornithine building blocks Andreas Link; Theo Lescrinier; Luc Kerremans; Jef Rozenski; Piet Herdewijn Pharmazie 53, 200-201 (1998) |
| 29 |
Practical method for the parallel synthesis of 2'-amido-2'-deoxyadenosines Andreas Link; Serge van Calenbergh; Piet Herdewijn Tetrahedron Letters 39, 5175-5176 (1998) |
1997 | |
| 30 |
Preparation of spiro[1-benzazepine-4,1'-cyclohexane] derivatives from 1H-1-benzazepine-2,5(3H,4H)-diones and Mannich bases Andreas Link; Conrad Kunick Synthesis 297-300 (1997) |
1996 | |
| 31 |
Synthesis and in vivo testing of a potential aquaretic agent Conrad Kunick; Andreas Link; Max Hropot Pharmazie 51, 601-602 (1996) |
| 32 |
Antitumoraktive Pyrido[3,2-d]-1-benzazepine Andreas Link -/- Betreuer: Conrad Kunick Dissertation, Hamburg (1996) |
1995 | |
| 33 |
Synthesis of pyrido[3,4-d]benzazepines Conrad Kunick; Andreas Link Journal of Heterocyclic Chemistry 32, 803-805 (1995) |
