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Synthetic Carbohydrate Chemistry
In this area we are involved in a number of different projects.
Some are concerned with methodology studies in glycosylation, e.g.
we are elaborating applications for the synthesis of variously glycosylated
natural products such as steroids and tocopherols. In further studies
we also deal with combinatorial glycosylations. Some other work
centered on carbohydrate mimetics employing sigmatropic rearrangements
of saccharide-derived allyl ketene acetals (Fig. 1) [1].
Figure.1: Carbohydrate mimetics
employing sigmatropic rearrangements of saccharide-derived allyl
ketene acetals [1].
Selected Publications
[1] S. Jürs, J. Thiem, Tetrahedron Asymm., 16, 1631-1638
(2005).
[2] L. Kröger, J. Thiem, J. Carbohydr. Chem. 24, 717 -712
(2005).
[3] A.M. Scheppokat, H. Bretting, J. Thiem, Carbohydr. Res.,
338, 2083-2090 (2003).
[4] B. Neubacher, D. Schmidt, P. Ziegelmüller, J. Thiem, Org.
Biomol. Chem. 3, 1551-1556 (2005).
[5] D. Henkensmeier, B. C. Abele, A. Candussio, J. Thiem, Macromol.
Chem. Phys., 205, 1851-1857 (2004).
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