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Inhalt:
Kurzbiographie
| 1940 | geboren in Hamburg |
| 1961-1967 | Chemie-Studium in Hamburg |
| 1967 | Diplom in Chemie bei Hans Paulsen in Hamburg |
| 1967 | Forschungsaufenthalt am Max-Planck-Institut für Biologie in Tübingen |
| 1968 | Promotion bei Friedrich Cramer am Max-Planck-Institut für Experimentalmedizin in Göttingen, eingereicht in Braunschweig |
| 1969-1972 | Assistent an der Universität Hamburg |
| 1972 | PostDoc bei Heinz Schaller am Max-Planck-Institut für Virusforschung in Tübingen |
| 1973 | Habilitation in Hamburg |
| 1973-1998 | Dozent/Professor an der Universität Hamburg |
| 1981 | Gründung der Firma Biosyntech |
| 1986 | Gründung der Firma Milligen/Biosearch |
| 1994 | Gründung der Firma Sequenom |
| 2008- | Scientific Advisory Board Member und CSO der caprotec bioanalytics GmbH |
Weitere Informationen
Besondere Leistungen
- Entwickelte eine Schutzgruppentechnik, die die moderne DNA-Synthese ermöglichte
Publikationen
(Nur die Publikationen aus der Hamburger Zeit bis 1998 werden im Gesamtindex der Chemie berücksichtigt. Publikationen nach 1998 sind derzeit nur in Auszügen aufgenommen.)2012 | |
| 189 |
Labeling and enrichment of Arabidopsis thaliana matrix metalloproteases using an active-site directed, marimastat-based photoreactive probe Janina Lenger, Farnusch Kaschani, Thomas Lenz, Christian Dalhoff, Joji Grace Villamor, Hubert Koester, Norbert Sewald, Renier A. L. van der Hoorn Bioorganic & Medicinal Chemistry 20, 592-596 (2012) |
| 188 |
Dabigatran and Dabigatran Ethyl Ester: Potent Inhibitors of Ribosyldihydronicotinamide Dehydrogenase (NQO2) Simon Michaelis, Anett Marais, Anna K. Schrey, Olivia Y. Graebner, Cornelia Schaudt, Michael Sefkow, Friedrich Kroll, Mathias Dreger, Mirko Glinski, Hubert Köster, Rainer Metternich, Jenny J. Fischer Journal of Medicinal Chemistry 55, 3934-3944 (2012) |
2011 | |
| 187 |
Improvement of Capture Compound mass spectrometry technology (CCMS) for the profiling of human kinases by combination with 2D LC-MS/MS Jenny J. Fischer, Olivia Graebner, Mathias Dreger, Mirko Glinski, Sabine Baumgart, Hubert Köster Journal of Biomedicine and Biotechnology 850589 (2011) |
| 186 |
SAHA Capture Compound - A novel tool for the profiling of histone deacetylases and the identification of additional vorinostat binders Jenny J. Fischer, Simon Michaelis, Anna K. Schrey, Anne Diehl, Olivia Y. Graebner, Jan Ungewiss, Sabine Horzowski, Mirko Glinski, Friedrich Kroll, Mathias Dreger, Hubert Köster Proteomics 11, 4096-4104 (2011) |
2010 | |
| 185 |
Synthesis of S-Adenosyl-L-homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases Christian Dalhoff, Michael Hüben, Thomas Lenz, Peter Poot, Eckhard Nordhoff, Hubert Köster, Elmar Weinhold ChemBioChem 11, 256-265 (2010) |
| 184 |
Comprehensive Identification of Staurosporine-Binding Kinases in the Hepatocyte Cell Line HepG2 using Capture Compound Mass Spectrometry (CCMS) Jenny J. Fischer, Olivia Y. Graebner, Christian Dalhoff, Simon Michaelis, Anna K. Schrey, Jan Ungewiss, Kathrin Andrich, Danny Jeske, Friedrich Kroll, Mirko Glinski, Michael Sefkow, Mathias Dreger, Hubert Köster Journal of Proteome Research 9, 806-817 (2010) |
| 183 |
GDP-Capture Compound - A novel tool for the profiling of GTPases in pro- and eukaryotes by capture compound mass spectrometry (CCMS) Yan Luo, Jenny J. Fischer, Olivia Y. Graebner, Anna K. Schrey, Jan Ungewiss, Mirko Glinski, Michael Sefkow, Mathias Dreger, Hubert Köster Journal of Proteomics 73, 815-819 (2010) |
| 182 |
Profiling of methyltransferases and other S-adenosyl-L-homocysteine-binding proteins by capture compound mass spectrometry (CCMS) Thomas Lenz, Peter Poot, Olivia Y. Graebner, Mirko Glinski, Elmar Weinhold, Mathias Dreger, Hubert Köster Journal of Visualized Experiments 46, 2264/1-2264/7 (2010) |
| 181 |
Capture Compounds for the functional isolation of nucleotide interacting proteins Erik Dülsner, Christian Jurinke, Hubert Köster Nature Methods 7, iii-iiv (2010) |
| 180 |
Capture Compound Mass Spectrometry Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs Jenny J. Fischer, Simon Michaelis, Anna K. Schrey, Olivia Y. Graebner, Mirko Glinski, Mathias Dreger, Friedrich Kroll, Hubert Köster Toxicological Sciences 113, 243-253 (2010) |
| 179 |
Capture compound mass spectrometry: A novel chemical proteomics approach to profile small molecule-protein interactions for drug target discovery and off-target binding-induced toxicity Michael Sefkow, Simon Michaelis, Christian Dalhoff, Jenny J. Fischer, Olivia Y. Graebner, Friedrich Kroll, Mirko Glinski, Mathias Dreger, Hubert Köster Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010 MEDI-M473 (2010) |
2009 | |
| 178 |
CCMS: a new era in toxicoproteomics Friedrich Kroll, Mirko Glinski, Mathias Dreger, Erik Dülsner, Hubert Köster Innovations in Pharmaceutical Technology 29, 38-41 (2009) |
| 177 |
The cAMP capture compound mass spectrometry as a novel tool for targeting cAMP-binding proteins: From protein kinase a to potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channels Yan Luo, Christian Blex, Olivia Baessler, Mirko Glinski, Mathias Dreger, Michael Sefkow, Hubert Köster Molecular and Cellular Proteomics 8, 2843-2856 (2009) |
| 176 |
Functional isolation of staurosporine binding protein kinases using CCMS technology Erik Dülsner, Jenny J. Fischer, Christian Jurinke, Hubert Köster Nature Methods 6, iii-iiv (2009) |
2007 | |
| 175 |
Capture compound mass spectrometry: a technology for the investigation of small molecule protein interactions Hubert Köster, Daniel P. Little, Peng Luan, Rolf Muller, Suhaib M. Siddiqi, Subramanian Marappan, Ping Yip Assay and Drug Development Technologies 5, 381-390 (2007) |
2004 | |
| 174 |
High density immobilization of nucleic acids and apparatus for dispensing nanovolumes of liquids and formation of multielement arrays Maryanne J. O'Donnell-Maloney, Charles R. Cantor, Hubert Köster -/- Anmelder: Sequenom Inc Patent: US 6818394 (B1) 2004-11-16 |
| 173 |
Capture compounds, collections thereof, methods for analyzing the proteome and complex compositions, and use in drug design Hubert Köster, Daniel P. Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, Ping Yip -/- Anmelder: HK Pharmaceuticals Inc, Hubert Köster, Daniel P. Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, Ping Yip Patent: WO 2004064972 (A2) 2004-08-05 |
2003 | |
| 172 |
Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions Hubert Köster, Suhaib Siddiqi, Daniel P. Little Patent: US 20030119021 (A1) 2003-06-26 |
2002 | |
| 171 |
Automated genotyping using the DNA MassArray technology Christian Jurinke, Dirk van den Boom, Charles R. Cantor, Hubert Köster Methods in Molecular Biology 187 (PCR Mutation Detection Protocols) 179-192 (2002) |
| 170 |
The use of MassARRAY technology for high throughput genotyping Christian Jurinke, Dirk van den Boom, Charles R. Cantor, Hubert Köster Advances in Biochemical Engineering/Biotechnology 77 (Chip Technology) 57-74 (2002) |
| 169 |
DNA
diagnostics based on mass spectrometry Hubert Köster, Kai Tang, Dong-Jing Fu, Carsten W. Siegert, Daniel P. Little, Andreas Braun, Brigitte Darnhofer-Demar, Christian Jurinke, Dirk van den Boom -/- Anmelder: Sequenom Inc Patent: US 6428955 (B1) 2002-08-06 |
| 168 |
Solid phase sequencing of double-stranded nucleic acids by array hybridization and mass spectrometry Dong-Jing Fu, Charles R. Cantor, Hubert Köster, Cassandra L. Smith -/- Anmelder: Boston University, Sequenom Inc Patent: US 6436635 (B1) 2002-08-20 |
2001 | |
| 167 |
DNA sequencing and genotyping by transcriptional synthesis of chain-terminated RNA ladders and MALDI-TOF mass spectrometry Young-Soo Kwon, Kai Tang, Charles R. Cantor, Hubert Köster, Changwon Kang Nucleic Acids Research 29, e11/1-e11/6 (2001) |
| 166 |
High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Kenneth H. Buetow, Michael Edmonson, Richard MacDonald, Robert Clifford, Ping Yip, Jenny Kelley, Daniel P. Little, Robert Strausberg, Hubert Köster, Charles R. Cantor, Andreas Braun Proceedings of the National Academy of Sciences of the United States of America 98, 581-584 (2001) |
| 165 |
MassARRAY: Highly accurate and versatile high throughput analysis of genetic variations Hubert Köster Focus on Structural Biology 2 (Mass Spectrometry and Genomic Analysis) 33-49 (2001) |
| 164 |
Automated genotyping using the DNA MassArray technology Christian Jurinke, Dirk van den Boom, Charles R. Cantor, Hubert Köster Methods in Molecular Biology 170 (DNA Arrays) 103-116 (2001) |
| 163 |
DNA sequencing by mass spectrometry Hubert Köster -/- Anmelder: Sequenom Inc Patent: US 6194144 (B1) 2001-02-27 |
| 162 |
Mass spectrometric detection of polypeptides Daniel P. Little, Hubert Köster, G. Scott Higgins, David Lough -/- Anmelder: Sequenom Inc Patent: US 6322970 (B1) 2001-11-27 |
| 161 |
Databases for identifying genetic polymorphisms as diagnostic markers and methods for their construction and use Andreas Braun, Hubert Köster, Dirk van den Boom, Ping Yip, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke -/- Anmelder: Sequenom Inc, Andreas Braun, Hubert Köster, Dirk van den Boom, Ping Yip, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke Patent: WO 2001027857 (A2) 2001-04-19 |
2000 | |
| 160 |
Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors Sabine Müller, Dirk van den Boom, Dorothea Zirkel, Hubert Köster, Frank Berthold, Manfred Schwab, Manfred Westphal, Walter Zumkeller Human Molecular Genetics 9, 757-763 (2000) |
| 159 |
Mass spectrometry of single-stranded restriction fragments captured by an undigested complementary sequence Normal H. L. Chiu, Kai Tang, Ping Yip, Andreas Braun, Hubert Köster, Charles R. Cantor Nucleic Acids Research 28, e31, ii-e31, iv (2000) |
| 158 |
Detection of genes and alleles associated with disease by mass spectrometric detection of nucleic acid hybridization Hubert Köster, G. Scott Higgins, Daniel P. Little -/- Anmelder: Sequenom Inc Patent: US 6043031 (A) 2000-03-28 |
| 157 |
DNA sequencing by mass spectrometry via exonuclease degradation Hubert Köster -/- Anmelder: Sequenom Inc Patent: US 6074823 (A) 2000-06-13 |
| 156 |
Increasing the area of a surface bearing immobilized oligonucleotide probes by immobilizing beads carrying probes on a flat surface Hubert Köster, David M. Lough -/- Anmelder: Sequenom Inc Patent: US 6133436 (A) 2000-10-17 |
| 155 |
Microreactor systems and methods for performing reactions in an unsealed environment Thomas Becker, Hubert Köster, Charles R. Cantor -/- Anmelder: Sequenom Inc, Thomas Becker, Hubert Köster, Charles R. Cantor Patent: WO 2000056446 (A1) 2000-09-28 |
| 154 |
Automated process lines Hubert Köster, Ping Yip, Jhobe Steadman, Dirk Reuter, Richard MacDonald -/- Anmelder: Sequenom Inc, Hubert Köster, Ping Yip, Jhobe Steadman, Dirk Reuter, Richard MacDonald Patent: WO 2000060361 (A2) 2000-10-12 |
1999 | |
| 153 |
Miniaturized arrays for DNA analysis Maryanne J. O'Donnell, Hubert Köster BioMethods 10 (Microsystem Technology: A Powerful Tool for Biomolecular Studies) 399-415 (1999) |
| 152 |
Chip-based genotyping by mass spectrometry Kai Tang, Dong-Jing Fu, Dominique Julien, Andreas Braun, Charles R. Cantor, Hubert Köster Proceedings of the National Academy of Sciences of the United States of America 96, 10016-10020 (1999) |
| 151 |
Synthesis of new liquid phase carriers for use in large scale oligodeoxyribonucleotide synthesis in solution Ralf Wörl, Hubert Köster Tetrahedron 55, 2941-2956 (1999) |
| 150 |
The use of liquid phase carriers for large scale oligodeoxyribonucleotide synthesis in solution via phosphoramidite chemistry Ralf Wörl, Hubert Köster Tetrahedron 55, 2957-2972 (1999) |
| 149 |
Processes and kits for mass spectrometric determination of polypeptides Daniel P. Little, Hubert Köster, G. Scott Higgins, David Lough -/- Anmelder: Sequenom Inc Patent: WO 9912040 (A2) 1999-03-11 |
| 148 |
Mass spectrometric methods for nucleic acid sequencing Maryanne J. O'Donnell, Changwon Kang, Young-Soo Kwon, Young Tae Kim, Hubert Köster, Daniel P. Little, Guobing Xiang, David M. Lough, Charles R. Cantor -/- Anmelder: Sequenom Inc, Korea Advanced Institute of Science and Technology, Maryanne J. O'Donnell Patent: WO 9931278 (A1) 1999-06-24 |
| 147 |
Solution phase biopolymer synthesis of oligodeoxyribonucleotides using multifunctional liq. phase carriers Hubert Köster, Ralf Wörl Patent: WO 9955718 (A2) 1999-11-04 |
| 146 |
Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of biomacromolecules Franz Hillenkamp, Hubert Köster -/- Anmelder: Sequenom Inc, Franz Hillenkamp, Hubert Köster Patent: WO 9957318 (A2) 1999-11-11 |
1998 | |
| 145 |
Forward and reverse DNA sequencing in a single reaction Dirk van den Boom, Christian Jurinke, Andreas Ruppert, Hubert Köster Analytical Biochemistry 256, 127-129 (1998) |
| 144 |
Application of nested PCR and mass spectrometry for DNA-based virus detection: HBV-DNA detected in the majority of isolated anti-HBc positive sera Christian Jurinke, Bernhard Zöllner, Heinz-Hubert Feucht, Dirk van den Boom, Anette Jacob, Susanne Polywka, Rainer Laufs, Hubert Köster Genetic Analysis: Biomolecular Engineering 14, 97-102 (1998) |
| 143 |
Sequencing exons 5 to 8 of the p53 gene by MALDI-TOF mass spectrometry Dong-Jing Fu, Kai Tang, Andreas Braun, Dirk Reuter, Brigitte Darnhofer-Demar, Daniel P. Little, Maryanne J. O'Donnell, Charles R. Cantor, Hubert Köster Nature Biotechnology 16, 381-384 (1998) |
| 142 |
Mass spectrometric DNA diagnostics Dirk van den Boom, Christian Jurinke, Scott Higgins, Thomas Becker, Hubert Köster Nucleosides & Nucleotides 17, 2157-2164 (1998) |
| 141 |
Asymmetric polymerase chain reaction improves streptavidin-biotin based purification of polymerase chain reaction products prior to matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis Christian Jurinke, Dirk van den Boom, Hubert Köster Rapid Communications in Mass Spectrometry 12, 50-52 (1998) |
| 140 |
Compositions and methods for immobilizing macromolecules on solid supports David M. Lough, Hubert Köster, Dirk Reuter, G. Scott Higgins -/- Anmelder: Sequenom Inc, David M. Lough, Hubert Köster, Dirk Reuter, G. Scott Higgins Patent: WO 9820019 (A1) 1998-05-14 |
| 139 |
High density immobilization of nucleic acids and apparatus for dispensing nanovolumes of liquids and formation of multielement arrays Maryanne J. O'Donnell, Charles R. Cantor, Daniel P. Little, Hubert Köster -/- Anmelder: Sequenom Inc, Maryanne J. O'Donnell, Charles R. Cantor, Daniel P. Little, Hubert Köster Patent: WO 9820020 (A2) 1998-05-14 |
| 138 |
DNA sequencing diagnostics based on mass spectrometry Hubert Köster, Kai Tang, Dong-Jing Fu, Carsten W. Siegert, Daniel P. Little, G. Scott Higgins, Andreas Braun, Brigitte Damhoffer-Demar, Christian Jurinke, Dirk van der Boom, Guobing Xiang, David M. Lough -/- Anmelder: Sequenom Inc, Hubert Köster, Kai Tang, Dong-Jing Fu, Carsten W. Siegert, Daniel P. Little, G. Scott Higgins, Andreas Braun, Brigitte Damhoffer-Demar, Christian Jurinke, Dirk van den Boom, Guobing Xiang, David M. Lough Patent: WO 9820166 (A2) 1998-05-14 |
| 137 |
A reversible conjugation of biomolecules to solid supports for nucleic acid sequencing, amplification and detection Hubert Köster Patent: WO 9833808 (A2) 1998-08-06 |
1997 | |
| 136 |
Recovery of nucleic acids from immobilized biotin-streptavidin complexes using ammonium hydroxide and applications in MALDI-TOF mass spectrometry Christian Jurinke, Dirk van den Boom, Verena Collazo, Anke Lüchow, Anette Jacob, Hubert Köster Analytical Chemistry 69, 904-910 (1997) |
| 135 |
High-Density, Covalent Attachment of DNA to Silicon Wafers for Analysis by MALDI-TOF Mass Spectrometry Maryanne J. O'Donnell-Maloney, Kai Tang, Hubert Köster, Cassandra L. Smith, Charles R. Cantor Analytical Chemistry 69, 2438-2443 (1997) |
| 134 |
MALDI on a Chip: Analysis of Arrays of Low-Femtomole to Subfemtomole Quantities of Synthetic Oligonucleotides and DNA Diagnostic Products Dispensed by a Piezoelectric Pipet Daniel P. Little, Timothy J. Cornish, Maryanne J. O'Donnell, A. Braun, Robert J. Cotter, Hubert Köster Analytical Chemistry 69, 4540-4546 (1997) |
| 133 |
Competitive oligonucleotide single-base extension combined with mass spectrometric detection for mutation screening G. Scott Higgins, Daniel P. Little, Hubert Köster BioTechniques 23, 710-714 (1997) |
| 132 |
Detecting CFTR gene mutations by using primer oligo base extension and mass spectrometry Andreas Braun, Daniel P. Little, Hubert Köster Clinical Chemistry 43, 1151-1158 (1997) |
| 131 |
Identification of apolipoprotein E polymorphisms using temperature cycled primer oligo base extension and mass spectrometry Daniel P. Little, Andreas Braun, Brigitte Darnhofer-Demar, Hubert Köster European Journal of Clinical Chemistry and Clinical Biochemistry 35, 545-548 (1997) |
| 130 |
Improved analysis of microsatellites using mass spectrometry Andreas Braun, Daniel P. Little, Dirk Reuter, Bertram Müller-Mysok, Hubert Köster Genomics 46, 18-23 (1997) |
| 129 |
Direct
detection of synthetic and biologically generated double-stranded DNA by MALDI-TOF MS Daniel P. Little, Anette Jacob, Thomas Becker, Andreas Braun, Brigitte Darnhofer-Demar, Christian Jurinke, Dirk van den Boom, Hubert Köster International Journal of Mass Spectrometry and Ion Processes 169/170, 323-330 (1997) |
| 128 |
Combined amplification and sequencing in a single reaction using two DNA polymerases with differential incorporation rates for dideoxynucleotides Dirk van den Boom, Andreas Ruppert, Christian Jurinke, Hubert Köster Journal of Biochemical and Biophysical Methods 35, 69-79 (1997) |
| 127 |
Detection of RET proto-oncogene codon 634 mutations using mass spectrometry Daniel P. Little, Andreas Braun, Brigitte Darnhofer-Demar, Andrea Frilling, Yunzhi Li, Robert T. McIver, Hubert Köster Journal of Molecular Medicine 75, 745-750 (1997) |
| 126 |
Mass spectrometry from miniaturized arrays for full comparative DNA analysis Daniel P. Little, Andreas Braun, Maryanne J. O'Donnell, Hubert Köster Nature Medicine 3, 1413-1416 (1997) |
| 125 |
Sequencing double-stranded DNA by strand displacement Dong-Jing Fu, Hubert Köster, Cassandra L. Smith, Charles R. Cantor Nucleic Acids Research 25, 677-679 (1997) |
| 124 |
DNA analysis by mass spectrometry:applications in DNA sequencing and DNA diagnostics Hubert Köster, Dirk van den Boom, A. Braun, Anette Jacob, Christian Jurinke, Daniel P. Little, Kai Tang Nucleosides & Nucleotides 16, 563-571 (1997) |
| 123 |
DNA sequencing after the human genome project Charles R. Cantor, Kai Tang, Joel H. Graber, Maryanne Maloney, Dong-Jing Fu, Natalia E. Broude, Fouad Siddiqi, Hubert Köster, Cassandra L. Smith Nucleosides & Nucleotides 16, 591-598 (1997) |
| 122 |
The future of DNA sequencing, as seen after the Human Genome Project Charles R. Cantor, Cassandra L. Smith, Dong-Jing Fu, Natalia E. Broude, Ron Yaar, Maryanne Maloney, Kai Tang, Joel H. Graber, Daniel P. Little, Hubert Köster, Robert J. Cotter NATO ASI Series, Series 3: High Technology 31 (Genome Structure and Function) 239-260 (1997) |
| 121 |
DNA detection and diagnostics based on mass spectrometry Hubert Köster -/- Anmelder: Sequenom Inc Patent: US 5605798 (A) 1997-02-25 |
| 120 |
Apparatus and process for multi-stage solid-phase synthesis of long-chained organic molecules Stephen Allen, Hubert Köster, Edward Ashare, Donald W. Euwart, Jennifer Fernandes -/- Anmelder: Hybridon Inc Patent: WO 9707126 (A1) 1997-02-27 |
| 119 |
A method for processing large number of samples to isolate plasmids using a filtration procedure Hubert Köster Patent: WO 9708306 (A1) 1997-03-06 |
| 118 |
Nucleic acid sequencing by mass spectrometry Hubert Köster -/- Anmelder: Sequenom Inc Patent: WO 9737041 (A2) 1997-10-09 |
| 117 |
A combinatorial protecting group strategy for the solid phase preparation of oligodeoxyribonucleotides Hubert Köster, Eckart Leikauf Patent: WO 9741139 (A2) 1997-11-06 |
| 116 |
Direct sequencing of DNA during enzymic amplification of the template using pairs of DNA polymerases with different affinities for chain-terminating nucleotides Hubert Köster, Dirk van den Boom, Andreas Ruppert -/- Anmelder: Sequenom Inc Patent: WO 9742348 (A1) 1997-11-13 |
| 115 |
Method for dissociating biotin complexes Christian Jurinke, Dirk van den Boom, Hubert Köster -/- Anmelder: Sequenom Inc Patent: WO 9743617 (A2) 1997-11-20 |
1996 | |
| 114 |
Analysis of ligase chain reaction products via matrix-assisted-laser desorption/ionization time-of-flight-mass spectrometry Christian Jurinke, Dirk van den Boom, Anette Jacob, Kai Tang, Ralf Wörl, Hubert Köster Analytical Biochemistry 237, 174-181 (1996) |
| 113 |
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the detection of polymerase chain reaction products containing 7-deazapurine moieties Carsten W. Siegert, Anette Jacob, Hubert Köster Analytical Biochemistry 243, 55-65 (1996) |
| 112 |
High-Resolution MALDI Fourier Transform Mass Spectrometry of Oligonucleotides Yunzhi Li, Kai Tang, Daniel P. Little, Hubert Köster, Richard L. Hunter, Robert T. McIver Analytical Chemistry 68, 2090-2096 (1996) |
| 111 |
Efficient preparation of short DNA sequence ladders potentially suitable for MALDI-TOF DNA sequencing Dong-Jing Fu, Natalia E. Broude, Hubert Köster, Cassandra L. Smith, Charles R. Cantor Genetic Analysis: Biomolecular Engineering 12, 137-142 (1996) |
| 110 |
Detection of hepatitis B virus DNA in serum samples via nested PCR and MALDI-TOF mass spectrometry Christian Jurinke, Bernhard Zöllner, Heinz-Hubert Feucht, Anette Jacob, Jörn Kirchhübel, Anke Lüchow, Dirk van den Boom, Rainer Laufs, Hubert Köster Genetic Analysis: Biomolecular Engineering 13, 67-71 (1996) |
| 109 |
A strategy for rapid and efficient DNA sequencing by mass spectrometry Hubert Köster, Kai Tang, Dong-Jing Fu, Andreas Braun, Dirk van den Boom, Cassandra L. Smith, Robert J. Cotter, Charles R. Cantor Nature Biotechnology 14, 1123-1128 (1996) |
| 108 |
Sanger DNA sequencing by mass spectrometry using base-specific chain termination and elongation, primer modification, nested fragments, reversible immobilization, and tag-specific probes Hubert Köster -/- Anmelder: Sequenom Inc Patent: US 5547835 (A) 1996-08-20 |
| 107 |
Fast, reliable, and accurate method for detection of nucleic acid in biological sample by nucleic acid isolation, amplification, and mass spectrometry Hubert Köster -/- Anmelder: Sequenom Inc Patent: WO 9629431 (A2) 1996-09-26 |
| 106 |
Methods and kits nucleic acid detection and sequencing, especially using mass-modified nucleic acid probe arrays Charles R. Cantor, Hubert Köster, Cassandra L. Smith, Dong-Jing Fu -/- Anmelder: Boston University Patent: WO 9632504 (A2) 1996-10-17 |
1995 | |
| 105 |
A filtration method for plasmid isolation using microtiter filter plates Andreas Ruppert, Beata Szalay, Dirk van den Boom, Gernot Horst, Hubert Köster Analytical Biochemistry 230, 130-134 (1995) |
| 104 |
Matrix-assisted laser desorption/ionization mass spectrometry of immobilized duplex DNA probes Kai Tang, Dong-Jing Fu, Sven Kötter, Robert J. Cotter, Charles R. Cantor, Hubert Köster Nucleic Acids Research 23, 3126-3131 (1995) |
| 103 |
A DNA sequencing strategy that requires only five bases of known terminal sequence for priming Dong-Jing Fu, Natalia E. Broude, Hubert Köster, Cassandra L. Smith, Charles R. Cantor Proceedings of the National Academy of Sciences of the United States of America 92, 10162-10166 (1995) |
| 102 |
Hetero-bifunctional trityl derivatives as linking reagents for the recovery of nucleic acids after labeling and immobilization Eckart Leikauf, Frank Barnekow, Hubert Köster Tetrahedron 51, 3793-3802 (1995) |
| 101 |
A new colorimetric protecting group allowing deprotection under neutral conditions Eckart Leikauf, Hubert Köster Tetrahedron 51, 5557-5562 (1995) |
1994 | |
| 100 |
DNA sequencing by mass spectrometry Hubert Köster Patent: WO 9416101 (A2) 1994-07-21 |
| 99 |
DNA sequencing by mass spectrometry of exonuclease-generated sequential degradation products Hubert Köster Patent: WO 9421822 (A1) 1994-09-29 |
1991 | |
| 98 |
Functionalized membrane supports for covalent protein microsequence analysis James M. Coull, Darryl J. C. Pappin, Jonathan Mark, Ruedi Aebersold, Hubert Köster Analytical Biochemistry 194, 110-120 (1991) |
| 97 |
Oligonucleotide synthesis and multiplex DNA sequencing using chemiluminescent detection Hubert Köster, Stephan Beck, James M. Coull, T. Dunne, Brian D. Gildea, C. Kissinger, Thomas O'Keeffe Nucleic Acids Symposium Series 24 (Synth. Oligonucleotides: Probl. Front. Pract. Appl.) 318-321 (1991) |
| 96 |
Immobilization of proteins and peptides on insoluble supports for sequencing and other applications Darryl J. C. Pappin, James M. Coull, Hubert Köster -/- Anmelder: Millipore Corp Patent: EP 410323 (A2) 1991-01-30 |
| 95 |
Reversible modification of biological compounds for detection, separation and purification thereof James M. Coull, Brian D. Gildea, Hubert Köster -/- Anmelder: Millipore Corp Patent: EP 424819 (A1) 1991-05-02 |
1990 | |
| 94 |
Solid-phase sequence analysis of proteins electroblotted or spotted onto polyvinylidene difluoride membranes Darryl J. C. Pappin, James M. Coull, Hubert Köster Analytical Biochemistry 187, 10-19 (1990) |
| 93 |
Applications of dioxetane chemiluminescent probes to molecular biology Stephan Beck, Hubert Köster Analytical Chemistry 62, 2258-2270 (1990) Erratum: Analytical Chemistry 63, 848-848 (1991) |
| 92 |
A versatile acid-labile linker for modification of synthetic biomolecules Brian D. Gildea, James M. Coull, Hubert Köster Tetrahedron Letters 31, 7095-7098 (1990) |
| 91 |
Recent developments in solid phase peptide synthesis using the 9-fluorenylmethyoxycarbonyl (Fmoc) protecting group strategy Michael S. Bernatowicz, Scott B. Daniels, James M. Coull, Thomas Kearney, Richard S. Neves, Peter J. Coassin, Hubert Köster Curr. Res. Protein Chem.: Tech., Struct., Funct., [Pap. Annu. Symp. Protein Soc.], 3rd 63-77 (1990) |
| 90 |
New approaches to covalent sequence analysis Darryl J. C. Pappin, James M. Coull, Hubert Köster Curr. Res. Protein Chem.: Tech., Struct., Funct., [Pap. Annu. Symp. Protein Soc.], 3rd 191-202 (1990) |
| 89 |
Membranes
as novel solid supports for peptide synthesis Scott B. Daniels, Michael S. Bernatowicz, James M. Coull, Hubert Köster -/- Herausgeber: J. E. Rivier, G. R. Marshall Peptides: Structure and Biology Proceedings of the Eleventh American Peptide Symposium 1027-1028 (1990) |
| 88 |
Membranes for solid phase protein sequencing James M. Coull, Darryl J. C. Pappin, Hubert Köster, Malcolm G. Pluskal, Michael J. Steuck, Alex G. Bonner -/- Anmelder: Millipore Corp Patent: EP 353460 (A2) 1990-02-07 |
| 87 |
Detecting and sequencing nucleic acids using chemiluminescence Stephan Beck, James M. Coull, Hubert Köster, Thomas J. O'Keeffe -/- Anmelder: Millipore Corp Patent: WO 9010718 (A1) 1990-09-20 |
1989 | |
| 86 |
A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers Jeffrey D. Hermes, Shirish M. Parekh, Stephen C. Blacklow, Hubert Köster, Jeremy R. Knowles Gene 84, 143-151 (1989) |
| 85 |
New bacteriophage vectors for the large scale production of single stranded insert DNA Jacek Biernat, Ulf B. Göbel, Hubert Köster Journal of Biochemical and Biophysical Methods 19, 155-167 (1989) |
| 84 |
Preparation of single stranded insert DNA free of vector sequences Jacek Biernat, Ulf B. Göbel, Hubert Köster Nucleic Acids Research 17, 810-810 (1989) |
| 83 |
Chemiluminescent detection of DNA: application sequencing and hybridization Stephen Beck, Thomas O'Keeffe, James M. Coull, Hubert Köster Nucleic Acids Research 17, 5115-5123 (1989) |
| 82 |
An efficient method for racemization free attachment of 9-fluorenylmethyloxycarbonyl amino acids to peptide synthesis supports Michael S. Bernatowicz, Thomas Kearney, Richard S. Neves, Hubert Köster Tetrahedron Letters 30, 4341-4344 (1989) |
| 81 |
Membranes as solid supports for peptide synthesis Scott B. Daniels, Michael S. Bernatowicz, James M. Coull, Hubert Köster Tetrahedron Letters 30, 4345-4348 (1989) |
| 80 |
A comparison of acid-labile linkage agents for the synthesis of peptide C-terminal amides Michael S. Bernatowicz, Scott B. Daniels, Hubert Köster Tetrahedron Letters 30, 4645-4648 (1989) |
| 79 |
Preparation of modified polymer membranes as supports for the solid phase synthesis of oligonucleotides and peptides Hubert Köster, James M. Coull -/- Anmelder: Millipore Corp Patent: EP 305929 (A2) 1989-03-08 |
1988 | |
| 78 |
The construction, cloning, and expression of synthetic genes coding for totally artificial proteins Hubert Köster, Jacek Biernat, H. Hasselmann, Bernd Hofer, Nick Kennedy Nucleosides & Nucleotides 7, 683-686 (1988) |
| 77 |
Synthetic food protein genes and their expression, and use of the protein in diets for treatment of liver insufficiency and phenylketonuria Hubert Köster, Jacek Biernat, Nick Kennedy, Bernd Hofer -/- Anmelder: Biosyntech GmbH Patent: EP 285675 (A1) 1988-10-12 |
1987 | |
| 76 |
Escherichia coli RNA polymerase binding to a DNA terminus prevents formation of a closed promoter complex Bernd Hofer, Dieter Müller, Hubert Köster Biochimica et Biophysica Acta, Gene Structure and Expression 910, 254-260 (1987) |
| 75 |
Negative ion FAB mass spectrometric analysis of non-charged key intermediates in oligonucleotide synthesis: rapid identification of partially protected dinucleoside monophosphates Andreas Wolter, Claudius Möhringer, Hubert Köster, Wilfried A. König Biomedical & Environmental Mass Spectrometry 14, 111-116 (1987) |
| 74 |
The construction and cloning of synthetic genes coding for artificial proteins and expression studies to obtain fusion proteins Jacek Biernat, Hanne Hasselmann, Bernd Hofer, Nick Kennedy, Hubert Köster Protein Engineering 1, 345-351 (1987) |
| 73 |
Expression of synthetic genes coding for completely new, nutritionally rich, artificial proteins Jacek Biernat, Hubert Köster Protein Engineering 1, 353-358 (1987) |
1986 | |
| 72 |
New type of linker useful for cloning experiments Hubert Köster, Jörg Blieffert Journal of Biochemical and Biophysical Methods 13, 251-257 (1986) |
| 71 |
Polymer support oligonucleotide synthesis. XX. Synthesis of a henhectacosa deoxynucleotide by use of a dimeric phosphoramidite synthon Andreas Wolter, Jacek Biernat, Hubert Köster Nucleosides & Nucleotides 5, 65-77 (1986) |
1985 | |
| 70 |
Immunochemical studies on biosynthesis of rat plasma angiotensinogen and its regulation by cortisol Jürgen Voigt, Hubert Köster Biochimica et Biophysica Acta, General Subjects 842, 100-107 (1985) |
| 69 |
The pathway of E. coli RNA polymerase-promoter complex formation as visualized by footprinting Bernd Hofer, Dieter Müller, Hubert Köster Nucleic Acids Research 13, 5995-6013 (1985) |
| 68 |
Some improvements of polymer oligodeoxynucleotide synthesis Hubert Köster, Jacek Biernat, J. McManus, Nanda D. Sinha Studies in Organic Chemistry 20 (Nat. Prod. Chem.) 227-237 (1985) |
| 67 |
Verfahren zur definierten Verknüpfung doppelhelikaler DNA-Fragmente mittels einer Linker-DNA sowie als Linker-DNA geeignete Oligonucletide (Defined connected double helical DNA-fragments by means of a linkage DNA as well as linkage DNA-suitable oligonucleotides) Hubert Köster Patent: DE 3326520 (A1) 1985-01-31 |
| 66 |
Oligonucleotides Hubert Köster, Nanda Dual Sinha -/- Anmelder: Hubert Köster Patent: DE 3329892 (A1) 1985-03-07 |
1984 | |
| 65 |
Polymer support oligonucleotide synthesis. XVIII: use of β-cyanoethyl-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product Nanda D. Sinha, Jacek Biernat, J. McManus, Hubert Köster Nucleic Acids Research 12, 4539-4557 (1984) |
| 64 |
Polymer support oligonucleotide synthesis. XVI. Synthesis of oligonucleotides using suitably protected deoxynucleoside N-morpholinophosphoramidites on porous glass beads Nanda D. Sinha, Jacek Biernat, Hubert Köster Nucleosides & Nucleotides 3, 157-171 (1984) |
| 63 |
Polymer support oligonucleotide synthesis - XV. Synthesis of oligodeoxynucleotides on controlled pore glass (CPG) using phosphate and a new phosphite triester approach Hubert Köster, Jacek Biernat, J. McManus, Andreas Wolter, A. Stumpe, C. K. Narang, Nanda D. Sinha Tetrahedron 40, 103-112 (1984) |
| 62 |
Verfahren zur Herstellung von Oligonucleotiden (Oligonucleotides) Hubert Köster Patent: DE 3239887 (A1) 1984-05-03 |
| 61 |
Verfahren zur Herstellung von Oligonucleosidphosphonaten (Oligonucleoside phosphonates) Hubert Köster Patent: DE 3239888 (A1) 1984-05-03 |
1983 | |
| 60 |
Aspects of the mechanism of acid-phenol extraction of nucleic acids Dieter Müller, Bernd Hofer, Annie Koch, Hubert Köster Biochimica et Biophysica Acta, Gene Structure and Expression 740, 1-7 (1983) |
| 59 |
Polymer support oligonucleotide synthesis. 13. Rapid and efficient synthesis of oligodeoxynucleotides on porous glass support using triester approach Hubert Köster, A. Stumpe, Andreas Wolter Tetrahedron Letters 24, 747-750 (1983) |
| 58 |
Purification orientated synthesis of oligodeoxynucleotides in solution Jacek Biernat, Andreas Wolter, Hubert Köster Tetrahedron Letters 24, 751-754 (1983) |
| 57 |
Anthranilic acid: a new coreagent for the deblocking of 2,2,2-trichloroethylphosphate protecting groups Andreas Wolter, Hubert Köster Tetrahedron Letters 24, 873-876 (1983) |
| 56 |
A new synthesis of oligodeoxynucleoside methylphosphinates on control pore glass polymer support using phosphite approach Nanda D. Sinha, V. Großbruchhaus, Hubert Köster Tetrahedron Letters 24, 877-880 (1983) |
| 55 |
β-Cyanoethyl N,N-dialkylamino/N-morpholinomonochlorophosphoamidites, new phosphitylating agents facilitating ease of deprotection and work-up of synthesized oligonucleotides Nanda D. Sinha, Jacek Biernat, Hubert Köster Tetrahedron Letters 24, 5843-5846 (1983) |
| 54 |
Verfahren zur Abspaltung von Tritylschutzgruppen (Cleavage of trityl protective groups) Hubert Köster, Nanda D. Sinha -/- Anmelder: Hubert Köster Patent: DE 3208565 (A1) 1983-11-10 |
1982 | |
| 53 |
Purification and characterization of two forms of rat plasma proangiotensin Jürgen Voigt, Brigitte Wittmann-Liebold, Hubert Köster European Journal of Biochemistry 122, 183-191 (1982) |
| 52 |
Primary and secondary structure specificity of the cleavage of single-stranded DNA by endonuclease HinfI Bernd Hofer, Gabriela Ruhe, Annie Koch, Hubert Köster Nucleic Acids Research 10, 2763-2773 (1982) |
| 51 |
Synthesis of oligodeoxynucleotide diesters and oligodeoxynucleotide phosphonate-diesters using phosphate- and phosphite-triester approach Hubert Köster, Jacek Biernat, V. Großbruchhaus, J. McManus, D. Rotermund, Nanda D. Sinha, A. Stumpe, Andreas Wolter Nucleic Acids Symposium Series 11 (Symp. Nucleic Acids Chem., 10th, 1982) 101-104 (1982) |
| 50 |
Dialkylaluminum chloride: a reagent for removal of trityl group from trityl ethers of deoxynucleosides, deoxynucleotides, and oligodeoxynucleotides Hubert Köster, Nanda D. Sinha Tetrahedron Letters 23, 2641-2644 (1982) |
1981 | |
| 49 |
Enzymic synthesis, ligation, and restriction of DNA containing deoxy-4-thiothymidine Bernd Hofer, Hubert Köster Nucleic Acids Research 9, 753-767 (1981) |
| 48 |
N-acyl
protecting groups for deoxynucleosides. A quantitative and comparative study Hubert Köster, Konrad Kulikowski, Thomas Liese, Wiebke Heikens, Vipin Kohli Tetrahedron 37, 363-369 (1981) |
| 47 |
Modification of viral promoter activity by thymidine analogs Bernd Hofer, Hubert Köster Antiviral Chemother.: Des. Inhib. Viral Funct., [Proc. Symp. Antiviral Chemother.] 75-88 (1981) |
1980 | |
| 46 |
Die Bedeutung der chemischen Synthese von DNS für die Gentechnologie (Role of chemical synthesis of DNA in gene technology) Hubert Köster Arzneimittel-Forschung 30, 548-557 (1980) |
| 45 |
The interaction of the EcoRI restriction endonuclease with its substrate. A physicochemical study employing natural and synthetic oligonucleotides and polynucleotides Margarete Goppelt, Alfred Pingoud, Günter Maass, Hubert Mayer, Hubert Köster, Ronald Frank European Journal of Biochemistry 104, 101-107 (1980) |
| 44 |
Induction of plasma proangiotensin by steroid hormones in nephrectomized rats Jürgen Voigt, Hubert Köster European Journal of Biochemistry 110, 57-65 (1980) |
| 43 |
Festphasensynthese von Oligonucleotiden, 11. Verwendung eines neuartigen hydrophilen Perlpolymerisats als Träger (Solid-state synthesis of oligonucleotides. Part 11. Use of a new hydrophilic bead polymerizate as carrier) Walter Heidmann, Hubert Köster Makromolekulare Chemie 181, 2495-2506 (1980) |
| 42 |
Festphasensynthese von Oligonucleotiden, 12. Reaktionskinetische Untersuchungen an einem quellbaren Perlpolymerisat von Acrylsäuremethylester (Solid-state synthesis of oligonucleotides. Part 12. Reaction kinetics studies on a swellable methyl acrylate bead polymerizate) Walter Heidmann, Hubert Köster Makromolekulare Chemie 181, 2507-2516 (1980) |
| 41 |
On the influence of thymidine analogs on the activity of phage fd promoters in vitro Bernd Hofer, Hubert Köster Nucleic Acids Research 8, 6143-6162 (1980) |
| 40 |
Some improvements in the synthesis of DNA of biological interest Hubert Köster, N. Hoppe, Vipin Kohli, Marianne Kröpelin, H. Kaut, Konrad Kulikowski Nucleic Acids Symposium Series 7 (Nucleic Acids Synth.: Appl. Mol. Biol. Genet. Eng.) 39-60 (1980) |
| 39 |
Phosphorylation of nucleosides using molecular sieves as acid scavengers Vipin Kohli, Helmut Blöcker, Hubert Köster Tetrahedron Letters 21, 501-502 (1980) |
| 38 |
The triphenylmethyl (trityl) group and its uses in nucleotide chemistry Vipin Kohli, Helmut Blöcker, Hubert Köster Tetrahedron Letters 21, 2683-2686 (1980) |
| 37 |
On the mechanism of bacteriophage fd promoters Hubert Köster, Bernd Hofer, H. H. G. Müller, Marianne Kröpelin -/- Herausgeber: Jacek Augustyniak Biol. Implic. Protein-Nucleic Acid Interact., [Proc. Int. Conf.] 488-506 (1980), Verlag: Adam Mickiewicz Univ. Press, Poznan |
| 36 |
Chemical synthesis of DNA - possibilities and applications Hubert Köster -/- Herausgeber: Wojciech J. Stec Phosphorus Chemistry Directed towards Biology: Lectures presented at the International Symposium on Phosphorus Chemistry Directed Towards Biology, Burzenin, Poland 25-28 September 1979, 181-196 (1980) |
1979 | |
| 35 |
Elimination of promoter function by base modification of DNA Bernd Hofer, Hubert Köster FEBS Letters 102, 87-90 (1979) |
| 34 |
Chemische DNA-Synthesen (Chemical synthesis of DNA) Hubert Köster Nachrichten aus Chemie, Technik und Laboratorium 27, 694-700 (1979) |
| 33 |
DNA chain length markers and the influence of base composition on electrophoretic mobility of oligodeoxyribonucleotides in polyacrylamide gels Ronald Frank, Hubert Köster Nucleic Acids Research 6, 2069-2087 (1979) |
1978 | |
| 32 |
Well-defined insoluble primers for the enzymic synthesis of oligo- and polynucleotides Hubert Köster, Klaus Albersmeyer, Dietrich Skroch Hoppe-Seyler's Zeitschrift für Physiologische Chemie 359, 1579-1589 (1978) |
| 31 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 1 Zielsetzung und Synthesestrategie (Synthesis of a structural gene for the peptide hormone angiotensin II, part 1. Objective and synthetic strategy) Hubert Köster, Helmut Blöcker, Ronald Frank, Stephan Geussenhainer, Wolfgang Kaiser Justus Liebigs Annalen der Chemie 839-853 (1978) |
| 30 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 2. Synthese der geschützten Mono-, Di- und Tridesoxyribonucleotide mit 5'-Phosphatgruppe durch direkte Phosphorylierung (Synthesis of a structural gene for the peptide hormone angiotensin II, part 2. Synthesis of protected mono-, di-, and trideoxyribonucleotides with 5'-phosphate group by direct phosphorylation) Hubert Köster, Helmut Blöcker, Ronald Frank, Stephan Geussenhainer, Walter Heidmann, Wolfgang Kaiser, Dietrich Skroch Justus Liebigs Annalen der Chemie 854-893 (1978) |
| 29 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 3. Synthese der Teilsequenzen d(A-T-A-T-T-C-A-T-C-C-C), d(T-T-A-A-A-A-G-G-G-A-T) und d(T-T-T-T-A-A) (Synthesis of a structural gene for the peptide hormone angiotensin II, part 3. Synthesis of the sequences d(A-T-A-T-T-C-A-T-C-C-C), d(T-T-A-A-A-A-G-G-G-A-T), and d(T-T-T-T-A-A)) Hubert Köster Justus Liebigs Annalen der Chemie 894-925 (1978) |
| 28 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 4. Synthese der Teilsequenz d(G-A-A-T-A-T-A-A-A-C-G) (Synthesis of a structural gene for the peptide hormone angiotensin II, part 4. Synthesis of the sequence d(G-A-A-T-A-T-A-A-A-C-G)) Wolfgang Kaiser, Hubert Köster Justus Liebigs Annalen der Chemie 926-940 (1978) |
| 27 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 5. Synthese der Teilsequenz d(G-A-T-C-G-C-G-T-T-T) (Synthesis of a structural gene for the peptide hormone angiotensin II, part 5. Synthesis of the sequence d(G-A-T-C-G-C-G-T-T-T)) Stephan Geussenhainer, Hubert Köster Justus Liebigs Annalen der Chemie 941-954 (1978) |
| 26 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 6. Synthese der Teilsequenz d(C-G-A-T-C-C-A-T-T-T-A) (Synthesis of a structural gene for the peptide hormone angiotensin II, part 6. Synthesis of the sequence d(C-G-A-T-C-C-A-T-T-T-A)) Helmut Blöcker, Hubert Köster Justus Liebigs Annalen der Chemie 955-970 (1978) |
| 25 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 7. Synthese der Teilsequenz d(T-A-A-A-T-G) (Synthesis of a structural gene for the peptide hormone angiotensin II, part 7. Synthesis of the sequence d(T-A-A-A-T-G)) Ronald Frank, Hubert Köster Justus Liebigs Annalen der Chemie 971-981 (1978) |
| 24 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 8. Sequenzanalyse der Teilsegmente mit Hilfe einer kleinen Hochspannungselektrophoreseapparatur (Synthesis of a structural gene for the peptide hormone angiotensin II, part 8. Sequence analysis of the segments with a small high-voltage electrophoresis apparatus) Helmut Blöcker, Hubert Köster Justus Liebigs Annalen der Chemie 982-990 (1978) |
| 23 |
Synthese eines Strukturgens für das Peptidhormon Angiotensin II, Teil 9. Ligation der Teilsequenzen zum kompletten Doppelstrang (Synthesis of a structural gene for the peptide hormone angiotensin II, part 9. Ligation of the partial sequences to the complete duplex) Helmut Blöcker, Ronald Frank, Hubert Köster Justus Liebigs Annalen der Chemie 991-1006 (1978) |
| 22 |
Synthese des phagenspezifischen Oligonucleotids d(T-A-A-A-T-C-A-A-A-A-A-T-C) (Synthesis of the phage-specific oligodeoxynucleotide d(T-A-A-A-T-C-A-A-A-A-A-T-C)) Hubert Köster, Helmut Blöcker Justus Liebigs Annalen der Chemie 1007-1023 (1978) |
1976 | |
| 21 |
Vernetzte Polymerisate mit aktivierten Estergruppen - ein vielseitig verwendbares Trägermaterial (Crosslinked polymer with activated ester groups - a versatile, available support material) Hubert Köster, Walter Heidmann Angewandte Chemie, International Edition in English 15, 546-547 (1976) Translated: Angewandte Chemie 88, 576-577 (1976) |
| 20 |
Oligonucleotidsynthese an einem polymeren Träger unter Vermeidung von Fehlsequenzen (Oligonucleotide synthesis on a polymeric support with avoidance of failure sequences) Walter Heidmann, Hubert Köster Angewandte Chemie, International Edition in English 15, 547-548 (1976) Translated: Angewandte Chemie 88, 577-578 (1976) |
| 19 |
Total synthesis of the structural gene of the human peptide hormone angiotensin II Hubert Köster Beckman Report 3-8 (1976) |
| 18 |
Automated chromatography of protected oligonucleotides with high separation efficiency Hubert Köster, Ronald Frank Chromatographia 9, 497-501 (1976) |
| 17 |
Auf den Spuren des Lebens : Biochemikern gelang Totalsynthese eines Gens Hubert Köster Uni HH: Berichte und Meinungen aus der Universität Hamburg 7 (42) 11-12 (1976) |
1975 | |
| 16 |
Total synthesis of a structural gene for the human peptide hormone angiotensin II Hubert Köster, Helmut Blöcker, Ronald Frank, Stephan Geussenhainer, Wolfgang Kaiser Hoppe-Seyler's Zeitschrift für Physiologische Chemie 356, 1585-1593 (1975) |
1974 | |
| 15 |
Notiz über eine verbesserte chromatographische Trennung von Oligonucleotiden (Chromatographic separation of oligonucleotides) Hubert Köster, Wolfgang Kaiser Justus Liebigs Annalen der Chemie 336-341 (1974) |
| 14 |
Synthesen von Desoxyoligonucleotiden an einem makroporösen Polystyrol (Syntheses of deoxyoligonucleotides on macroporous polystyrene) Hubert Köster, Friedrich Cramer Justus Liebigs Annalen der Chemie 946-958 (1974) |
| 13 |
Synthese der Desoxyoligonucleotide dT(pdT)7 und dTpdTpdApdCpdCpdTpdA an einem makroporösen Polystyrol (Synthesis of deoxyoligonucleotides dT(pdT)7 and dTpdTpdApdCpdCpdTpdA on macroporous polystyrene) Hubert Köster, Alfred Pollak, Friedrich Cramer Justus Liebigs Annalen der Chemie 959-966 (1974) |
| 12 |
Recent improvements in the synthesis of deoxyoligonucleotides Hubert Köster -/- Herausgeber: Z. Paryzek Recent Developments in Oligonucleotide Synthesis and Chemistry of Minor Bases of tRNA: International Conference; Poznan, September 13-14, 1974, 125-152 (1974) |
1973 | |
| 11 |
Ein neuer Träger für die Festphasensynthese von Oligomeren (New concept of the synthesis of oligodeoxyribonucleotides) Hubert Köster, Walter Heidmann Angewandte Chemie, International Edition in English 12, 859-860 (1973) Translated: Angewandte Chemie 85, 871-872 (1973) |
| 10 |
Reaktionskinetische untersuchungen an einem makroporösen unquellbaren polystyrol: Abspaltung von nucleosiden und nucleotiden, die über p-anisyldiphenylmethylätherbindung an das polymerisat gebunden sind (Kinetics of reactions on a macroporous, nonswellable polystyrene. Cleavage of nucleosides and nucleotides linked to the polymer by a p-anisyldiphenylmethyl ether bond) Hubert Köster, Friedrich Cramer Makromolekulare Chemie 167, 171-182 (1973) |
| 9 |
Möglichkeiten und Probleme der Synthese von Polynucleotiden mit biologisch sinnvoller Information an polymeren Trägern Hubert Köster Habilitationsschrift, Hamburg (1973) |
1972 | |
| 8 |
A Novel Carrier for the Solid Phase Synthesis of Oligomers Hubert Köster, Stephan Geussenhainer Angewandte Chemie, International Edition in English 11, 713-714 (1972) |
| 7 |
Synthese
von Oligonucleotiden an einem Popcorn-Polystyrol als polymerem Träger (Synthesis of oligonucleotides on a popcorn-polystyrene polymeric carrier)) Hubert Köster, Friedrich Cramer Justus Liebigs Annalen der Chemie 766, 6-15 (1972) |
| 6 |
Polymer-support oligonucleotide synthesis. VI. Use of inorganic carriers Hubert Köster Tetrahedron Letters 1527-1530 (1972) |
| 5 |
Polymer-support oligonucleotide synthesis. VII. Use of Sephadex LH 20 Hubert Köster, Kurt Heyns Tetrahedron Letters 13, 1531-1534 (1972) |
| 4 |
Polymer-support oligonucleotide synthesis. VIII. Use of polyethylene glycol Hubert Köster Tetrahedron Letters 13, 1535-1538 (1972) |
1969 | |
| 3 |
Zum Mechanismus der Nucleosidsynthese mit Polyphosphorsäure-phenylester (Mechanism of nucleoside synthesis wih phenyl polyphosphate) Hubert Köster, Gerhard Schramm Chemische Berichte 102, 3868-3876 (1969) |
1968 | |
| 2 |
Oligonucleotidsynthesen an polymeren Trägern Hubert Köster -/- Betreuer: Friedrich Cramer Dissertation, Braunschweig (1968) |
1967 | |
| 1 |
Synthese von 9-β-L-Sorbopyranosyl-adenin (9-β-L-xylo-Hexulopyranosyl-adenin) (Synthesis of 9-β-L-sorbopyranosyladenine (9-β-L-xylo-hexulopyranosyladenin)) Hans Paulsen, Hubert Köster, Kurt Heyns Chemische Berichte 100, 2669-2680 (1967) |
