Sie sind hier: UHH > Chemie > Institute und Abteilungen > Biochemie und Molekularbiologie > Publikationen > Jörg Andrä
Inhalt:
Kurzbiographie
| 1965 | geboren in Castrop-Rauxel |
| 1993-1997 | Wissenschaftlicher Mitarbeiter im BMBF-Projekt: "Molekularer Mechanismus der cytolytischen Reaktion von Entamoeba histolytica" |
| 1996 | Promotion bei Matthias Leippe (Bernhard-Nocht-Institut) in Hamburg |
| 1997-2002 | Wissenschaftlicher Assistent (C1) am Fachbereich Chemie, Abteilung für Biochemie und Molekularbiologie, Universität Hamburg |
| 2002-2005 | Wissenschaftlicher Mitarbeiter in der Laborgruppe Biophysik am Forschungszentrum Borstel im EU-Projekt ANEPID (Antimicrobial Endotoxin Neutralising Peptides to Combat Infectious Diseases, Klaus Brandenburg) |
| 2004 | Gastaufenthalt bei Satoshi Fukuoka am Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology, AIST-Shikoku, Takamatsu, Japan |
| 2005-2009 | Wissenschaftlicher Mitarbeiter in der Laborgruppe Biophysik am Forschungszentrum Borstel im SFB 617: Molekulare Mechanismen der epithelialen Abwehr (Thomas Gutsmann) |
| 2005 | Habilitation im Fachbereich Chemie der Universität Hamburg für das Fach Biochemie |
| 2006 | Verleihung der Lehrbefugnis (venia legendi) als Privatdozent an der Universität Hamburg für das Fach Biochemie |
| 2010-2011 | Projektleiter am Forschungszentrum Borstel |
| 2012 | W2-Professur für Organische Chemie und Biochemie an der Hochschule für Angewandte Wissenschaften (HAW) Hamburg |
Weitere Informationen
Alternative Namensschreibungen
- Jörg Peter Andrä
- Jörg Andrä
Publikationen
(nur bis zum Ende der Universität Hamburg Zeit, bis 2011)2011 | |
| 1 |
Structural features governing the activity of lactoferricin derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo Susana Sánchez-Gómez; Bostjan Japelj; Roman Jerala; Ignacio Moriyón; Mirian Fernández Alonso; José Leiva; Sylvie E. Blondelle; Jörg Andrä; Klaus Brandenburg; Karl Lohner; Guillermo Martinez de Tejada Antimicrobial Agents and Chemotherapy 55, 218-228 (2011) |
| 2 |
Peptide-based treatment of sepsis Klaus Brandenburg; Jörg Andrä; Patrick Garidel; Thomas Gutsmann Applied Microbiology and Biotechnology 90, 799-808 (2011) |
| 3 |
Biophysical investigations into the interactions of endotoxins with bile acids Satoshi Fukuoka; Walter Richter; Jörg Howe; Jörg Andrä; Manfred Rössle; Christian Alexander; Thomas Gutsmann; Klaus Brandenburg Innate Immunity Published online before print (2011) |
| 4 |
Online monitoring of metabolism and morphology of peptide-treated neuroblastoma cancer cells and keratinocytes Sabine Drechsler; Jörg Andrä Journal of Bioenergetics and Biomembranes 43, 275-285 (2011) |
| 5 |
Multiple Peptide Resistance Factor (MprF)-mediated Resistance of Staphylococcus aureus against Antimicrobial Peptides Coincides with a Modulated Peptide Interaction with Artificial Membranes Comprising Lysyl-Phosphatidylglycerol Jörg Andrä; Torsten Goldmann; Christoph M. Ernst; Andreas Peschel; Thomas Gutsmann Journal of Biological Chemistry 286, 18692-18700 (2011) |
| 6 |
Studies on Lactoferricin-derived Escherichia coli Membrane-active Peptides Reveal Differences in the Mechanism of N-Acylated Versus Nonacylated Peptides Dagmar Zweytick; Günter Deutsch; Jörg Andrä; Sylvie E. Blondelle; Ekkehard Vollmer; Roman Jerala; Karl Lohner Journal of Biological Chemistry 286, 21266-21276 (2011) |
2010 | |
| 7 |
Effective antimicrobial and anti-endotoxin activity of cationic peptides based on lactoferricin: a biophysical and microbiological study Klaus Brandenburg; Jörg Howe; Susana Sánchez-Gómez; Patrick Garidel; Manfred Rössle; Jörg Andrä; Roman Jerala; Dagmar Zweytick; Karl Lohner; Michael Rappolt; Sylvie E. Blondelle; Ignacio Moriyón; Guillermo Martinez de Tejada Anti-Infective Agents in Medicinal Chemistry 9, 9-22 (2010) |
| 8 |
Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis Malte U. Hammer; Annemarie Brauser; Claudia Olak; Gerald Brezesinski; Torsten Goldmann; Thomas Gutsmann; Jörg Andrä Biochemical Journal 427, 477-488 (2010) |
| 9 |
Molecular basis for endotoxin neutralization by amphipathic peptides derived from the α-helical cationic core-region of NK-lysin Klaus Brandenburg; Patrick Garidel; Satoshi Fukuoka; Jörg Howe; Michel H. J. Koch; Thomas Gutsmann; Jörg Andrä Biophysical Chemistry 150, 80-87 (2010) |
| 10 |
Conformational Properties of Arenicins: From the Bulk to the Air-Water Interface Oksana G. Travkova; Jörg Andrä; Helmuth Möhwald; Gerald Brezesinski ChemPhysChem 11, 3262-3268 (2010) |
| 11 |
Physicochemical and biological characterization of anti-endotoxin peptides and their influence on lipid properties Ina Kowalski; Yani Kaconis; Jörg Andrä; Iosu Razquin-Olazaran; Thomas Gutsmann; Guillermo Martinez de Tejada; Klaus Brandenburg Protein & Peptide Letters 17, 1328-1333 (2010) |
| 12 |
Langmuir monolayers at the liquid-air interface: a useful tool to study the interaction of membrane-active peptides with phospholipids Claudia Olak; Jörg Andrä; Gerald Brezesinski IUL Biotechnology Series 9 (Membrane-Active Peptides) 81-112 (2010) |
2009 | |
| 13 |
Interaction of melittin with phospholipid- and lipopolysaccharide-containing model membranes Maria Hanulova; Jörg Andrä; Patrick Garidel; Claudia Olak; Jörg Howe; Sergio S. Funari; Thomas Gutsmann; Klaus Brandenburg Anti-Infective Agents in Medicinal Chemistry 8, 17-27 (2009) |
| 14 |
Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes Jörg Andrä; Malte U. Hammer; Joachim Grötzinger; Igor Jakovkin; Buko Lindner; Ekkehard Vollmer; Henning Fedders; Matthias Leippe; Thomas Gutsmann Biological Chemistry 390, 337-349 (2009) |
| 15 |
Interactions between lipid A and serum proteins Jörg Andrä; Thomas Gutsmann; Mareike Müller; Andra B. Schromm Advances in Experimental Medicine and Biology 667 (Lipid A in Cancer Therapy) 39-51 (2009) |
| 16 |
Pathogens in sepsis: gram-negative bacterial PAMPS and PRRs Andra B. Schromm; Christian Alexander; Thomas Gutsmann; Jörg Andrä; Cordula Stamme Sepsis and Non-infectious Systemic Inflammation 79-108 (2009), Verlag: Wiley-VCH Verlag GmbH & Co |
2008 | |
| 17 |
The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum Christoph Gelhaus; Thomas Jacobs; Jörg Andrä; Matthias Leippe Antimicrobial Agents and Chemotherapy 52, 1713-1720 (2008) |
| 18 |
Structure and mode of action of the antimicrobial peptide arenicin Jörg Andrä; Igor Jakovkin; Joachim Grötzinger; Oliver Hecht; Anna D. Krasnosdembskaya; Torsten Goldmann; Thomas Gutsmann; Matthias Leippe Biochemical Journal 410, 113-122 (2008) |
| 19 |
Interfacial properties and structural analysis of the antimicrobial peptide NK-2 Claudia Olak; Annabel Muenter; Jörg Andrä; Gerald Brezesinski Journal of Peptide Science 14, 510-517 (2008) |
| 20 |
Surface Acoustic Wave Biosensor as a Tool to Study the Interaction of Antimicrobial Peptides with Phospholipid and Lipopolysaccharide Model Membranes Jörg Andrä; Arne Böhling; Thomas M. A. Gronewold; Ulrich Schlecht; Markus Perpeet; Thomas Gutsmann Langmuir 24, 9148-9153 (2008) |
| 21 |
Antimicrobial peptides Sylvie E. Blondelle; Roman Jerala; Primoz Pristovsek; Andreja Majerle; Mateja Zorko; Bostjan Japelj; Klaus Brandenburg; Jörg Andrä; Massimo Porro; Ignacio Moriyón Uría; José Leiva León; Guillermo Martinez De Tejada De Garaizabal; Dagmar Zweytick; Günter Deutsch; Karl Lohner Patent: WO 2008006125 (A1) 2008-01-17 |
2007 | |
| 22 |
Spectroscopic investigations into inactivation of bacterial virulence factors Klaus Brandenburg; Jörg Howe; Manfred Rössle; Jörg Andrä ACS Symposium Series 963 (New Approaches in Biomedical Spectroscopy) 410-420 (2007) |
| 23 |
Novel antiinflammatory and antiinfective agents Patrick Garidel; Jörg Andrä; Jörg Howe; Thomas Gutsmann; Klaus Brandenburg Anti-Infective Agents in Medicinal Chemistry 6, 185-200 (2007) |
| 24 |
Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis Jörg Andrä; Jörg Howe; Patrick Garidel; Manfred Rössle; Walter Richter; José Leiva León; Ignacio Moriyón; Rainer Bartels; Thomas Gutsmann; Klaus Brandenburg Biochemical Journal 406, 297-307 (2007) |
| 25 |
Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins Xi Chen; Jörg Howe; Jörg Andrä; Manfred Rössle; Walter Richter; Ana Paula Galvao da Silva; Alan M. Krensky; Carol Clayberger; Klaus Brandenburg Biochimica et Biophysica Acta, Biomembranes 1768, 2421-2431 (2007) |
| 26 |
Thermodynamic analysis of the lipopolysaccharide-dependent resistance of Gram-negative bacteria against polymyxin B Jörg Howe; Jörg Andrä; Raquel Conde; Maite Iriarte; Patrick Garidel; Michel H. J. Koch; Thomas Gutsmann; Ignacio Moriyón; Klaus Brandenburg Biophysical Journal 92, 2796-2805 (2007) |
| 27 |
Rationale for the Design of Shortened Derivatives of the NK-lysin-derived Antimicrobial Peptide NK-2 with Improved Activity against Gram-negative Pathogens Jörg Andrä; Daniel Monreal; Guillermo Martinez de Tejada; Claudia Olak; Gerald Brezesinski; Susana Sánchez-Gómez; Torsten Goldmann; Rainer Bartels; Klaus Brandenburg; Ignacio Moriyón Journal of Biological Chemistry 282, 14719-14728 (2007) |
| 28 |
The Acyl Group as the Central Element of the Structural Organization of Antimicrobial Lipopeptide Bostjan Japelj; Mateja Zorko; Andreja Majerle; Primoz Pristovsek; Susana Sánchez-Gómez; Guillermo Martinez de Tejada; Ignacio Moriyón; Sylvie E. Blondelle; Klaus Brandenburg; Jörg Andrä; Karl Lohner; Roman Jerala Journal of the American Chemical Society 129, 1022-1023 (2007) |
2006 | |
| 29 |
Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity Dagmar Zweytick; Georg Pabst; Peter M. Abuja; Alexander Jilek; Sylvie E. Blondelle; Jörg Andrä; Roman Jerala; Daniel Monreal; Guillermo Martinez de Tejada; Karl Lohner Biochimica et Biophysica Acta, Biomembranes 1758, 1426-1435 (2006) |
| 30 |
Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization Jörg Andrä; Jörg Rademann; Jörg Howe; Michel H. J. Koch; Holger Heine; Ulrich Zähringer; Klaus Brandenburg Biological Chemistry 387, 301-310 (2006) |
| 31 |
Dissection of the mechanisms of cytolytic and antibacterial activity of lysenin, a defence protein of the annelid Eisenia fetida Heike Bruhn; Julia Winkelmann; Christian Andersen; Jörg Andrä; Matthias Leippe Developmental & Comparative Immunology 30, 597-606 (2006) |
| 32 |
Biophysical characterization of synthetic rhamnolipids Jörg Howe; Jörg Bauer; Jörg Andrä; Andra B. Schromm; Martin Ernst; Manfred Rössle; Ulrich Zähringer; Jörg Rademann; Klaus Brandenburg FEBS Journal 273, 5101-5112 (2006) |
| 33 |
Mechanisms of endotoxin neutralization by synthetic cationic compounds Jörg Andrä; Thomas Gutsmann; Patrick Garidel; Klaus Brandenburg Journal of Endotoxin Research 12, 261-277 (2006) |
| 34 |
What can calorimetry tell us about changes of three-dimensional aggregate structures of phospholipids and glycolipids? Klaus Brandenburg; Patrick Garidel; Jörg Howe; Jörg Andrä; L. Hawkins; Michel H. J. Koch; Ulrich Seydel Thermochimica Acta 445, 133-143 (2006) |
2005 | |
| 35 |
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide Jörg Andrä; Karl Lohner; Sylvie E. Blondelle; Roman Jerala; Ignacio Moriyón; Michel H. J. Koch; Patrick Garidel; Klaus Brandenburg Biochemical Journal 385, 135-143 (2005) |
| 36 |
Structural rearrangement of model membranes by the peptide antibiotic NK-2 Regine Willumeit; Mont Kumpugdee; Sergio S. Funari; Karl Lohner; Beatriz Pozo Navas; Klaus Brandenburg; Sebastian Linser; Jörg Andrä Biochimica et Biophysica Acta, Biomembranes 1669, 125-134 (2005) |
| 37 |
Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity Patrick Garidel; Michael Rappolt; Andra B. Schromm; Jörg Howe; Karl Lohner; Jörg Andrä; Michel H. J. Koch; Klaus Brandenburg Biochimica et Biophysica Acta, Biomembranes 1715, 122-131 (2005) |
| 38 |
Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide Klaus Brandenburg; Alexander David; Jörg Howe; Michel H. J. Koch; Jörg Andrä; Patrick Garidel Biophysical Journal 88, 1845-1858 (2005) |
| 39 |
Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part II. Mesomorphic properties Götz Milkereit; Klaus Brandenburg; Sven Gerber; Michel H. J. Koch; Michael Morr; Jörg Andrä; Ulrich Seydel; Volkmar Vill Chemistry and Physics of Lipids 135, 15-26 (2005) |
| 40 |
Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes Klaus Brandenburg; Patrick Garidel; Andra B. Schromm; Jörg Andrä; Arjen Kramer; Maarten Egmond; Andre Wiese European Biophysics Journal 34, 28-41 (2005) |
| 41 |
Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity Ulrich Seydel; Andra B. Schromm; Lore Brade; Sabine Gronow; Jörg Andrä; Mareike Müller; Michel H. J. Koch; Koichi Fukase; Mikayo Kataoka; Masaya Hashimoto; Shoichi Kusumoto; Klaus Brandenburg FEBS Journal 272, 327-340 (2005) |
| 42 |
The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine Hannah Schröder-Borm; Rumiana Bakalova; Jörg Andrä FEBS Letters 579, 6128-6134 (2005) |
| 43 |
Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection Thomas Jacobs; Jörg Andrä; Iris Gaworski; Sebastian Graefe; Katja Mellenthin; Manfred Krömer; Roman Halter; Jürgen Borlak; Joachim Clos Medical Microbiology and Immunology 194, 143-149 (2005) |
| 44 |
Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: Physicochemical characterization and biological activity Jörg Andrä; Hans de Cock; Patrick Garidel; Jörg Howe; Klaus Brandenburg Medicinal Chemistry 1, 537-546 (2005) |
| 45 |
Die duale Funktion von Antimikrobiellen Peptiden: Antibiotische Wirkung und Endotoxin Neutralisierung. Von den molekularen Mechanismen zur Wirkstoffentwicklung Jörg Andrä Habilitationsschrift, Hamburg (2005) |
2004 | |
| 46 |
Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin Jörg Andrä; Michel H. J. Koch; Rainer Bartels; Klaus Brandenburg Antimicrobial Agents and Chemotherapy 48, 1593-1599 (2004) |
| 47 |
Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide Jörg Andrä; Marta Lamata; Guillermo Martinez de Tejada; Rainer Bartels; Michel H. J. Koch; Klaus Brandenburg Biochemical Pharmacology 68, 1297-1307 (2004) |
| 48 |
Structural Polymorphism and Endotoxic Activity of Synthetic Phospholipid-like Amphiphiles Klaus Brandenburg; L. Hawkins; Patrick Garidel; Jörg Andrä; Mareike Müller; Holger Heine; Michel H. J. Koch; Ulrich Seydel Biochemistry 43, 4039-4046 (2004) |
| 49 |
Physicochemical characterization of the endotoxins from Coxiella burnetii strain Priscilla in relation to their bioactivities Rudolf Toman; Patrick Garidel; Jörg Andrä; Katarina Slaba; Ahmed Hussein; Michel H. J. Koch; Klaus Brandenburg BMC Biochemistry 5, 1-11 (2004) |
| 50 |
Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide Jörg Andrä; Patrick Garidel; Andreja Majerle; Roman Jerala; Richard Ridge; Erik Paus; Tom Novitsky; Michel H. J. Koch; Klaus Brandenburg European Journal of Biochemistry 271, 2037-2046 (2004) |
| 51 |
Membrane lipid composition protects Entamoeba histolytica from self-destruction by its pore-forming toxins Jörg Andrä; Otto Berninghausen; Matthias Leippe FEBS Letters 564, 109-115 (2004) |
| 52 |
Complement Inactivation by Recombinant Human C3 Derivatives Johanna Kölln; Edzard Spillner; Jörg Andrä; Katrin Klensang; Reinhard Bredehorst Journal of Immunology 173, 5540-5545 (2004) |
2003 | |
| 53 |
Molecular basis for membrane selectivity of NK-2, a potent peptide antibiotic derived from NK-lysin Hannah Schröder-Borm; Regine Willumeit; Klaus Brandenburg; Jörg Andrä Biochimica et Biophysica Acta, Biomembranes 1612, 164-171 (2003) |
| 54 |
Physicochemical properties of bacterial glycopolymers in relation to bioactivity Klaus Brandenburg; Jörg Andrä; Mareike Müller; Michel H. J. Koch; Patrick Garidel Carbohydrate Research 338, 2477-2489 (2003) |
| 55 |
Amoebapores, archaic effector peptides of protozoan origin, are discharged into phagosomes and kill bacteria by permeabilizing their membranes Jörg Andrä; Rosa Herbst; Matthias Leippe Developmental & Comparative Immunology 27, 291-304 (2003) |
| 56 |
Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans Klaus Brandenburg; Frauke Wagner; Mareike Müller; Holger Heine; Jörg Andrä; Michel H. J. Koch; Ulrich Zähringer; Ulrich Seydel European Journal of Biochemistry 270, 3271-3279 (2003) |
| 57 |
Cross-linked Hemoglobin Converts Endotoxically Inactive Pentaacyl Endotoxins into a Physiologically Active Conformation Klaus Brandenburg; Patrick Garidel; Jörg Andrä; Gudrun Jürgens; Mareike Müller; Alfred Blume; Michel H. J. Koch; Jack Levin Journal of Biological Chemistry 278, 47660-47669 (2003) |
2002 | |
| 58 |
Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins Klaus Brandenburg; Gudrun Jürgens; Jörg Andrä; Buko Lindner; Michel H. J. Koch; Alfred Blume; Patrick Garidel European Journal of Biochemistry 269, 5972-5981 (2002) |
| 59 |
Generation and characterization of transgenic mice expressing cobra venom factor Jörg Andrä; Roman Halter; Michael A. Kock; Heiner Niemann; Carl-Wilhelm Vogel; Dieter Paul Molecular Immunology 39, 357-365 (2002) |
2001 | |
| 60 |
Cecropins, antibacterial peptides from insects and mammals, are potently fungicidal against Candida albicans Jörg Andrä; Otto Berninghausen; Matthias Leippe Medical Microbiology and Immunology 189, 169-173 (2001) |
1999 | |
| 61 |
Candidacidal activity of shortened synthetic analogs of amoebapores and NK-lysin Jörg Andrä; Matthias Leippe Medical Microbiology and Immunology 188, 117-124 (1999) |
1997 | |
| 62 |
Molecular basis of aggressive and defensive functions of Entamoeba histolytica Claudia Benkert; Thomas Jacobs; Otto Berninghausen; Jörg Andrä; Matthias Leippe Archives of Medical Research 28 (Spec. Issue) 152-153 (1997) |
| 63 |
Potency of amoebapores compared to that of other membrane-permeating peptides Jörg Andrä; Otto Berninghausen; Matthias Leippe Archives of Medical Research 28 (Spec. Issue) 156-157 (1997) |
1996 | |
| 64 |
Shortened amoebapore analogs with enhanced antibacterial and cytolytic activity Jörg Andrä; Otto Berninghausen; Jan Wülfken; Matthias Leippe FEBS Letters 365, 96-100 (1996) |
| 65 |
Amoebapores, cytolytische und antibakterielle Peptide aus Entamoeba histolytica : Untersuchung der Struktur-Funktionsbeziehungen Jörg Andrä (= Jörg Peter Andrä) -/- Betreuer: Matthias Leippe Dissertation, Hamburg (1996) |
1994 | |
| 66 |
Pore-forming peptide of Entamoeba histolytica. Significance of positively charged amino acid residues for its mode of action Jörg Andrä; Matthias Leippe FEBS Letters 354, 97-102 (1994) |
| 67 |
Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes Matthias Leippe; Jörg Andrä; Rose Nickel; Egbert Tannich; Hans J. Müller-Eberhard Molecular Microbiology 14, 895-904 (1994) |
| 68 |
Cytolytic and antibacterial activity of synthetic peptides derived from amoebapore, the pore-forming peptide of Entamoeba histolytica Matthias Leippe; Jörg Andrä; Hans J. Müller-Eberhard Proceedings of the National Academy of Sciences of the United States of America 91, 2602-2606 (1994) |
