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Universität Hamburg Fachbereich Chemie



Inhalt:


Dr. Lars Redecke

BMBF Junior Research Group
"Structural Infection Biology Using new Radiation Sources (SIAS)"
of the Universities Lübeck and Hamburg (SIAS Homepage)

Laboratory for Structural Biology of Infection and Inflammation
c/o DESY, Build. 22a - Notkestr. 85 - 22603 Hamburg - Germany

Phone: 040 / 8998 - 5389, Fax: - 4747
E-Mail: Redecke@chemie.uni-hamburg.de
             Redecke@biochem.uni-luebeck.de

Curriculum:
Study of Chemistry at the University of Hamburg; Diploma Thesis (2000) and Dissertation (2005) in the Department of Chemistry, University of Hamburg; Research Assistant at the University Hospital Hamburg-Eppendorf, Group of Macromolecular Structural Analysis (2003-2006);  Research Assistant at the Institute of Biochemistry and Molecular Biology, University of Hamburg (2007-2008). Research Assistant at the Max-Planck Unit for Structural Moelcular Biology, Hamburg (2009).

Since 01.12.2009 Head of the cooperative BMBF Junior Research Group "Structural Infection Biology using new Radiation Sources (SIAS)" of the Universities Lübeck and Hamburg.

Cooperations:
Alfred-Wegener Institute for Polar and Marine Research (AWI), Helgoland , Germany (Dr. R. Saborowski); Centre for Environmental Research (UFZ) Leipzig, Germany (PD Dr. M. von Bergen); Altagen Inc., Ontario, Canada (Dr. R. Preddie); Robert-Koch-Institute, Berlin, Germany (Dr. M. Baier); EMBL Outstation, Hamburg, Germany (Dr. W. Meyer-Klaucke, Dr. D.I. Svergun); Institute for Applied Physics, University of Hamburg, Germany (Prof. M. Rübhausen); Centro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, Cuba (Prof. María de los Ángeles Chávez); Institute of Organic Chemistry, University of Hamburg, Germany (Prof. B. Meyer). Max-Planck Unit for Structural Molecular Biology, Hamburg (Prof. E. Mandelkow); Institute of Biochemistry, University of Lübeck (Prof. R. Hilgenfeld); Institute of Virology and Cell Biology, University of Lübeck (Prof. N. Tautz); Heinrich-Pette-Institute, Hamburg (Prof. H. Will); Department of Internal Medicine, AG Hepatology, University Hospital Hamburg-Eppendorf (Dr. M. Dandri).





Research Interests


Structural Infection Biology using new Radiation Sources

[more]


Publications


2010

R. Gracia-Fernandez, L. Redecke, T. Pons, M. Perbandt, D. Gil, A. Talavera, Y. Gonzalez, M. de los AngelesChavez. Structural basis for serine proetase inhibition by the recombinant Kunitz type inhibitor-I from the Carribbean sea anemone Stichodactyla helianthus: Crystal structures of the free and trypsin-complexed inhibitors. J. Mol. Biol. to be submitted (2010).

A. Andreyeva, I. Leshchyns'ka, M. Knepper, C. Betzel, L. Redecke, V. Sytnyk, M. Schachner. CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex. PLoS One 5:e12018 (2010).

D. Georgieva, L. Redecke, M. von Bergen, N. Genov, C. Betzel. Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein. Protein Pept. Lett.17:399-404 (2010).

2009

L. Redecke, S. Binder, M.I.Y. Elmallah, R. Broadbent, C. Tilkorn, B. Schulz, P. May, A. Goos, A. Eich, M. Rübhausen, Ch. Betzel. UV light induced conversion and aggregation of prion proteins. Free Radic. Biol. Med. 15:1353-1361 (2009).

D. Rehders, B. Claasen,  L. Redecke, A. Buschke, C. Reibe, N. Jehmlich, M. von Bergen, Ch. Betzel, B. Meyer.  Octapeptide NMHRYPNQ of the cellular prion protein (PrPC) inhibits aggregation and is a potential key for understanding prion prion interactions.J. Mol. Biol. 392:198-207 (2009).

2008

L. Redecke*, J.H. Hehemann*, J. Murugaiyan, M. von Bergen, Ch. Betzel, R. Saborowski. Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus. Biochem. Biophys. Res. Commun. 370:566-571 (2008).

2007

J.H. Hehemann, L. Redecke, M. Perbandt, R. Saborowski, Ch. Betzel. Crystallization and preliminary X-ray diffraction studies of trypsin-like proteases from the gastric fluid of the marine crab Cancer pagurus. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 63:242-245 (2007)

G. Zoldák, L. Redecke, D.I. Svergun, P.V. Konarev, S. Voertler, H. Dobbek, E. Sedlák, M. Sprinzl. Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalo-rimetric studies. Nuc. Acids. Res. 35:1343-1353 (2007)

L. Redecke, M.A. Brehm, R. Bredehorst. Cloning and characterization of dihydrofolate reductase from a facultative alkaliphilic and halotolerant Bacillus strain. Extremophiles 11:75-83 (2007)

L. Redecke, M. von Bergen, J. Clos, P.V. Konarev, D.I. Svergun, U.E.A. Fittschen, J.A.C. Broekaert, O. Bruns, D. Georgieva, E. Mandelkow, N. Genov, Ch. Betzel. Structural characterization of β-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro. J. Struct. Biol. 157:308-320 (2007)

2006

D. Georgieva, D. Schwark, M. von Bergen, L. Redecke, N. Genov, Ch. Betzel. Interactions of recombinant prions with compounds of therapeutical significance. Biochem. Biophys. Res. Commun. 344:463-470 (2006)

2005

L. Redecke, W. Meyer-Klaucke, M. Koker, J. Clos, D. Georgieva, N. Genov, H. Echner, H. Kalbacher, M. Perbandt, R. Bredehorst, W. Voelter, Ch. Betzel. Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5. J. Biol. Chem. 280:13987-13992 (2005)

2004

D. Georgieva, W. Rypniewski, H. Echner, M. Perbandt, M. Koker, J. Clos, L. Redecke, R. Bredehorst, W. Voelter, N. Genov, Ch. Betzel. Synthetic human prion protein octapeptide repeat binds to the proteinase K active site. Biochem. Biophys. Res. Commun. 325:1406-1411 (2004)

D. Georgieva, M. Koker, L. Redecke, M. Perbandt, J. Clos, R. Bredehorst, N. Genov, Ch. Betzel. Oligomerization of the proteolytic products is an intrinsic property of prion proteins. Biochem. Biophys. Res. Commun. 323:1278-1286 (2004)


Invited Talks

L.Redecke (2009). Prion Protein Aggregation induced by Oxidative Stress: Insights into the Mechanism of Conversion and Specific Inhibition. IV International Symposium on Biochemistry and Molecular Biology, October 12th to 16th 2009, International Conference Center, Havana City, Cuba.

L. Redecke (2005). Prions – Proteinaceous Infectious Particles. Universidade Estadual Paulista (UNESP) Sao Jose do Rio Preto, SP, Brazil.

L. Redecke (2005).  Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.


Posters

L. Redecke, S. Binder, M.Y.I. Elmallah, B. Schulz, P. May, A. Goos, M. Rübhausen, Ch. Betzel (2008). UV radiation induces specific conversion and aggregation of prion proteins. International Conference "Prion2008", 08.-10. October 2008, Madrid, Spain.

L. Redecke, M. von Bergen, M. Silvestric, W. Meyer-Klaucke, D. I. Svergun, P. V. Konarev, D. Georgieva, N. Genov,  Ch. Betzel (2007). Metal ion coordination to oligomeric intermediates on the pathway of oxidative prion protein aggregation. International Conference "Prion2007", 26.-28. September 2007, Edinburgh, Scotland.

L. Redecke, J. Bergmann, R. Bergmann, Ch. Betzel, E. Preddie (2007). Mimicking pathological conversion of Prion protein to PrP(Sc) in vitro. International Conference "Prion2007", 26.-28. September 2007, Edinburgh, Scotland.

R. Saborowski, L. Redecke, J.-H. Hehemann, Ch. Betzel, M. von Bergen (2007). A novel enzyme with tryptic activity from the gastric fluid of the marine crab Cancer pagurus. 100. Annual Meeting of the German Zoological Society, 21.–25. September, Cologne, Germany.

L. Redecke, M. von Bergen, M. Silvestric, W. Meyer-Klaucke, D. I. Svergun, P.V. Konarev, D. Georgieva, N. Genov,  Ch. Betzel (2007). Oxidative stress forces prion proteins to convert and to form beta-sheeted aggregates that retain the ability to coordinate metal ions. GMB-Fall Meeting, 16.-19. September 2007, Hamburg, Germany.

L. Redecke, M. Silvestric, M. von Bergen, D.I. Svergun, P.V. Konarev, D. Georgieva, N. Genov, Ch. Betzel (2006). Structurally distinct β-sheeted oligomers are formed on the pathway of oxidative prion protein aggregation in vitro. Final Meeting of the national TSE Researchplatform Germany, 26.-28. June 2006, Greifswald, Germany.

L. Redecke, M. von Bergen, W. Meyer-Klaucke, D.I. Svergun, J. Clos, D. Georgieva, N. Genov, Ch. Betzel (2005). Structural Investigation of Human Prion Protein Aggregation induced by Metal-Catalyzed Oxidation. International Conference "Prion 2005", 19.-21. October 2005, Duesseldorf, Germany.

L. Redecke, M. von Bergen, W. Meyer-Klaucke, D. Svergun, J. Clos, D. Georgieva, N. Genov, Ch. Betzel (2005). Solution structure of an intermediate on the pathway of human prion protein aggregation. GBM-Fall Meeting, 18.-21. September 2005, Berlin, Germany.

L. Redecke, D. Georgieva, M. Koker, W. Meyer-Klaucke, J. Clos, N. Genov, H. Echner, M. Perbandt, R. Bredehorst, W. Voelter, Ch. Betzel (2005). Structural Investigations of Prion Protein Aggregation. 2nd International Symposium on the new Prion Biology: Basic Science, Diagnosis and Therapy. 7.-9. April 2005, Venice, Italy.

L. Redecke, (2003). International Conference „Prion Diseases: from basic research to intervention concepts“ 8.–10. October 2003, Munich, Germany.

L. Redecke, R. Bredehorst, J. Andrä (2000). Purification and Characterization of Dihydrofolate Reductase (DHFR) from thermophilic Bacillus thermoleovorans.The 3rd International Congress on Extremophiles, 3.-7. September 2000, Hamburg, Germany.


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