Dr. Lars Redecke BMBF-Nachwuchsgruppe "Strukturelle Infektionsbiologie unter Anwendung neuer Strahlungsquellen (SIAS)" der Universitäten Lübeck und Hamburg Laboratorium für Strukturbiologie von Infektion und Entzündung c/o DESY, Geb. 22a - Notkestr. 85 - 22603 Hamburg Telefon: 040 / 8998 - 5389, Fax: - 4747 E-Mail: Redecke@chemie.uni-hamburg.de              Redecke@biochem.uni-luebeck.de Wissenschaftlicher Werdegang: Studium der Chemie an der Universität Hamburg; Diplomarbeit (2000) und Promotion (2005) am Fachbereich Chemie der Universität Hamburg; Wissenschaftlicher Mitarbeiter am Universitätskrankenhaus Hamburg-Eppendorf, Abt. für makromolekulare Struktur- analyse (2003-2006);  Wissenschaftlicher Mitarbeiter am Institut für Biochemie und Molekularbiologie der Universität Hamburg (2007-2008); Wissenschaftlicher Mitarbeiter der Max-Planck-Arbeitsgruppen für Strukturelle Molekularbiologie, Hamburg (2009); Seit 01.12.2009 Leiter der gemeinsamen BMBF-Nachwuchsgruppe "Strukturelle Infektionsbiologie unter Anwendung neuer Strahlungsquellen (SIAS)" der Universitäten Lübeck und Hamburg. Kooperationen: Alfred-Wegener Institut für Polar und Meeresforschung, Helgoland (Dr. R. Saborowski); Umweltforschungszentrum (UFZ) Leipzig (PD Dr. M. von Bergen); Altagen Inc. (Ontario/Canada); Robert-Koch-Institut, Berlin (Dr. M. Baier); EMBL Outstation, Hamburg (Dr. W. Meyer-Klaucke, Dr. D.I. Svergun); Institut für Angewandte Physik, Universität Hamburg (Prof. M. Rübhausen); Centro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, Cuba (Prof. María de los Ángeles Chávez);Institut für Organische Chemie, Universität Hamburg (Prof. B. Meyer); Max-Planck-Arbeitsgruppen für Strukturelle Molekularbiologie, Hamburg (Prof. E. Mandelkow); Institut für Biochemie, Universität zu Lübeck (Prof. R. Hilgenfeld); Institut für Virologie und Zellbiologie, Universität zu Lübeck (Prof. N. Tautz); Heinrich-Pette-Institut, Hamburg (Prof. H. Will); Zentrum für innere Medizin, AG Hepatologie, Universitätsklinikum Hamburg-Eppendorf (Dr. M. Dandri).

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Forschungsgebiet

Strukturelle Infektionsbiologie unter Anwendung neuer Strahlungsquellen

[mehr]

Publikationen

2010

R. Gracia-Fernandez, L. Redecke, T. Pons, M. Perbandt, D. Gil, A. Talavera, Y. Gonzalez, M. de los AngelesChavez. Structural basis for serine proetase inhibition by the recombinant Kunitz type inhibitor-I from the Carribbean sea anemone Stichodactyla helianthus: Crystal structures of the free and trypsin-complexed inhibitors. J. Mol. Biol. to be submitted (2010).

A. Andreyeva, I. Leshchyns'ka, M. Knepper, C. Betzel, L. Redecke, V. Sytnyk, M. Schachner. CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex. PLoS One 5:e12018 (2010).

D. Georgieva, L. Redecke, M. von Bergen, N. Genov, C. Betzel. Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein. Protein Pept. Lett.17:399-404 (2010).

2009

D. Georgieva, L. Redecke, M. von Bergen, N. Genov, C. Betzel. Interactions of Ginkgolides A and B with a Recombinant Human Prion Protein. Protein Pept. Lett. (2009).

L. Redecke, S. Binder, M.I.Y. Elmallah, R. Broadbent, C. Tilkorn, B. Schulz, P. May, A. Goos, A. Eich, M. Rübhausen, Ch. Betzel. UV light induced conversion and aggregation of prion proteins. Free Radic. Biol. Med. 15:1353-1361 (2009).

D. Rehders, B. Claasen,  L. Redecke, A. Buschke, C. Reibe, N. Jehmlich, M. von Bergen, Ch. Betzel, B. Meyer.  Octapeptide NMHRYPNQ of the cellular prion protein (PrPC) inhibits aggregation and is a potential key for understanding prion prion interactions.J. Mol. Biol. 392:198-207 (2009).

2008

L. Redecke*, J.H. Hehemann*, J. Murugaiyan, M. von Bergen, Ch. Betzel, R. Saborowski. Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus. Biochem. Biophys. Res. Commun. 370:566-571 (2008).

2007

J.H. Hehemann, L. Redecke, M. Perbandt, R. Saborowski, Ch. Betzel. Crystallization and preliminary X-ray diffraction studies of trypsin-like proteases from the gastric fluid of the marine crab Cancer pagurus. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 63:242-245 (2007)

G. Zoldák, L. Redecke, D.I. Svergun, P.V. Konarev, S. Voertler, H. Dobbek, E. Sedlák, M. Sprinzl. Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalo-rimetric studies. Nuc. Acids. Res. 35:1343-1353 (2007)

L. Redecke, M.A. Brehm, R. Bredehorst. Cloning and characterization of dihydrofolate reductase from a facultative alkaliphilic and halotolerant Bacillus strain. Extremophiles 11:75-83 (2007)

L. Redecke, M. von Bergen, J. Clos, P.V. Konarev, D.I. Svergun, U.E.A. Fittschen, J.A.C. Broekaert, O. Bruns, D. Georgieva, E. Mandelkow, N. Genov, Ch. Betzel. Structural characterization of β-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro. J. Struct. Biol. 157:308-320 (2007)

2006

D. Georgieva, D. Schwark, M. von Bergen, L. Redecke, N. Genov, Ch. Betzel. Interactions of recombinant prions with compounds of therapeutical significance. Biochem. Biophys. Res. Commun. 344:463-470 (2006)

2005

L. Redecke, W. Meyer-Klaucke, M. Koker, J. Clos, D. Georgieva, N. Genov, H. Echner, H. Kalbacher, M. Perbandt, R. Bredehorst, W. Voelter, Ch. Betzel. Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5. J. Biol. Chem. 280:13987-13992 (2005)

2004

D. Georgieva, W. Rypniewski, H. Echner, M. Perbandt, M. Koker, J. Clos, L. Redecke, R. Bredehorst, W. Voelter, N. Genov, Ch. Betzel. Synthetic human prion protein octapeptide repeat binds to the proteinase K active site. Biochem. Biophys. Res. Commun. 325:1406-1411 (2004)

D. Georgieva, M. Koker, L. Redecke, M. Perbandt, J. Clos, R. Bredehorst, N. Genov, Ch. Betzel. Oligomerization of the proteolytic products is an intrinsic property of prion proteins. Biochem. Biophys. Res. Commun. 323:1278-1286 (2004)

Vorträge

L.Redecke (2009). Prion Protein Aggregation induced by Oxidative Stress: Insights into the Mechanism of Conversion and Specific Inhibition. IV International Symposium on Biochemistry and Molecular Biology, October 12th to 16th 2009, International Conference Center, Havana City, Cuba.

L. Redecke (2005). Prions – Proteinaceous Infectious Particles. Universidade Estadual Paulista (UNESP) Sao Jose do Rio Preto, SP, Brasilien.

L. Redecke (2005).  Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasilien.

Poster

L. Redecke, S. Binder, M.Y.I. Elmallah, B. Schulz, P. May, A. Goos, M. Rübhausen, Ch. Betzel (2008). UV radiation induces specific conversion and aggregation of prion proteins. International Conference "Prion2008", 08.-10. Oktober 2008, Madrid, Spanien.

L. Redecke, M. von Bergen, M. Silvestric, W. Meyer-Klaucke, D. I. Svergun, P. V. Konarev, D. Georgieva, N. Genov,  Ch. Betzel (2007). Metal ion coordination to oligomeric intermediates on the pathway of oxidative prion protein aggregation. International Conference "Prion2007", 26.-28. September 2007, Edinburgh, Schottland.

L. Redecke, J. Bergmann, R. Bergmann, Ch. Betzel, E. Preddie (2007). Mimicking pathological conversion of Prion protein to PrP(Sc) in vitro. International Conference "Prion2007", 26.-28. September 2007, Edinburgh, Schottland.

R. Saborowski, L. Redecke, J.-H. Hehemann, Ch. Betzel, M. von Bergen (2007). A novel enzyme with tryptic activity from the gastric fluid of the marine crab Cancer pagurus. 100. Jahrestagung der Deutschen Zoologischen Gesellschaft, 21.–25. September, Köln, Deutschland.

L. Redecke, M. von Bergen, M. Silvestric, W. Meyer-Klaucke, D. I. Svergun, P.V. Konarev, D. Georgieva, N. Genov,  Ch. Betzel (2007). Oxidative stress forces prion proteins to convert and to form beta-sheeted aggregates that retain the ability to coordinate metal ions. GMB-Herbsttagung, 16.-19. September 2007, Hamburg, Deutschland.

L. Redecke, M. Silvestric, M. von Bergen, D.I. Svergun, P.V. Konarev, D. Georgieva, N. Genov, Ch. Betzel (2006). Structurally distinct β-sheeted oligomers are formed on the pathway of oxidative prion protein aggregation in vitro. Abschluss-Treffen der nationalen TSE-Forschungsplattform, 26.-28. Juni 2006, Greifswald, Deutschland.

L. Redecke, M. von Bergen, W. Meyer-Klaucke, D.I. Svergun, J. Clos, D. Georgieva, N. Genov, Ch. Betzel (2005). Structural Investigation of Human Prion Protein Aggregation induced by Metal-Catalyzed Oxidation. International Conference "Prion 2005", 19.-21. Oktober 2005, Düsseldorf, Duetschland.

L. Redecke, M. von Bergen, W. Meyer-Klaucke, D. Svergun, J. Clos, D. Georgieva, N. Genov, Ch. Betzel (2005). Solution structure of an intermediate on the pathway of human prion protein aggregation. GBM-Herbsttagung, 18.-21. September 2005, Berlin, Deutschland.

L. Redecke, D. Georgieva, M. Koker, W. Meyer-Klaucke, J. Clos, N. Genov, H. Echner, M. Perbandt, R. Bredehorst, W. Voelter, Ch. Betzel (2005). Structural Investigations of Prion Protein Aggregation. 2nd International Symposium on the new Prion Biology: Basic Science, Diagnosis and Therapy. 7.-9. April 2005, Venedig, Italien.

L. Redecke, (2003). International Conference „Prion Diseases: from basic research to intervention concepts“ 8.–10. Oktober 2003, München, Deutschland.

L. Redecke, R. Bredehorst, J. Andrä (2000). Purification and Characterization of Dihydrofolate Reductase (DHFR) from thermophilic Bacillus thermoleovorans.The 3rd International Congress on Extremophiles, 3.-7. September 2000, Hamburg, Deutschland.